Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1995-11-14
1997-09-30
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
A61K 31135
Patent
active
056726287
DESCRIPTION:
BRIEF SUMMARY
The invention relates to the control of pest population, in particular harmful rodent and bird populations, by using baits having hormonal action.
Pests such as rats, when present in large numbers, cause great economic and hygienic harm in different parts of the world by spoiling grain and foodstuffs or by transmitting diseases to people and animals. Attempts have previously been made to control pest populations by using, for example, traps and poison baits.
It has now been discovered that when baits containing an antiestrogen or a progestin as an active substance are distributed in a pest-infested area during the reproduction period of the pests, the numbers of young and newborn individuals decrease rapidly. The hormonal baits according to the invention are not lethal to the pests; the baits reduce the reproductive capacity of the pests and thus control their population. The active substances according to the invention are more nature-friendly than are the poisons commonly used for pest control, and they have not been noted to change the normal behaviour of the pests. Furthermore the pests do not have any aversion to baits of the invention.
Pests for which the method according to the invention is suitable include in particular rodents such as rat, hare and rabbit, and birds such as crow, pigeon, sparrow and gull.
The active substances according to the invention are orally active antiestrogens and progestins. The orally active antiestrogen according to the invention is preferably a non-steroidal antiestrogen. Especially suitable are non-steroidal antiestrogens having a triphenylethylene structure. Examples of these compounds are tamoxifen, 4-hydroxytamoxifen, 3-hydroxytamoxifen, toremifene, N-demethyltoremifene, 4-hydroxytoremifene and clomiphene. Of progestins, progesterone can in particular be mentioned.
It has been observed that in a rodent, such as a rat, an antiestrogen very effectively prevents the embedding of the ovum. Thus an antiestrogen reduces the reproductive capacity of rodents. Bird populations can be controlled effectively with a progestin, which prevents fertilization and thereby the development of eggs into young ones. It has also been observed that progestin prevents the reproduction of rodents, and so progestin and antiestrogen can be used either alternatively or together for rodent population control.
The invention includes a method for controlling a pest population comprising administering an antiestrogen or a progestin to pests in an amount which controls their reproduction. Especially the invention includes a method for controlling a pest population in a geographical area comprising distributing a composition containing an orally active antiestrogen or progestin mixed with an edible carrier in the area. The invention also includes new bait compositions useful for controlling a pest population.
The baits according to the invention comprise an antiestrogen or a progestin mixed with an edible carrier such baits being palatable to the pest. The edible carrier means here any non-toxic substance palatable to the pest. The edible carrier may be, for example, a foodstuff or a feed. Especially suitable carriers include grain products, pieces of bread, flours, oils such as vegetable oils or fish oils, sugar, and various mixtures of these. The active substance and the edible carrier are mixed using known methods and the resulting bait compositions are distributed in the pest-infested area. The active substance according to the invention is preferably dissolved in a food oil before being mixed with the carrier. Preferred baits for rats are cakes made of wheat flour, water and food oil, the active substance being dissolved in the food oil. The bait cakes are preferably moistened with codliver oil to improve their palatability. The finished baits are distributed in the pest-infested area, preferably daily throughout the reproductive period of the pest. The baiting period preferably last at least one natural life span of the pest. For rats the baiting period is typically 1-2 years. A suitable amou
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Heiskanen, deceased Kalevi
Kangas Lauri
Orion-yhtyma Oy
Spivack Phyllis G.
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