Method for control of the volume flux of a liquid in an...

Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system

Reexamination Certificate

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Reexamination Certificate

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07976535

ABSTRACT:
The invention refers to a method for control of a volume flow in an osmotic micropump and an osmotic micropump. According to the invention, the osmotically driven volume flow of the solvent through the sempipermeable diaphragm of an osmotic micropump is controlled by the transfer of a solute, which is not freely permeable through the diaphragm, from a source chamber to the pump's delivery chamber. According to the invention, the delivery chamber is formed as a dilution chamber, wherein the solution is flow out along a convective dilution path close to the semipermeable diaphragm. Due to the entrance of the solvent, a stationary osmotic gradient can be achieved along the convective flow path in the dilution chamber. The invention allows the maintenance and control of the flow rate. It is able to move a volume which is large in comparison to the combined volume of the source chamber and the dilution chamber.

REFERENCES:
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patent: 4619652 (1986-10-01), Eckenhoff et al.
patent: 2001/0047161 (2001-11-01), Wong et al.
patent: 2003/0205582 (2003-11-01), Joshi et al.
patent: 41 06 624 (1992-09-01), None
patent: 4106624 (1992-09-01), None
patent: 1167757 (2002-01-01), None
patent: WO 94/05354 (1994-03-01), None
Theeuwes F., Yum S. I. Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations. Ann. Biomed. Eng. 4 (4), 343-353 (1976), Yu-Chuan Su, Liwei Lin and Alert P.Pissano, J. of Microelectromechanical Systems 11, 736-741, 2002.
International Search Report dated Jul. 5, 2005 for corresponding International Application No. PCT/DE2005/000393.
Partial automated translation of German Patent Application No. DE 4106624 submitted in the IDS filed on Nov. 3, 2006.

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