Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1998-04-28
2000-12-12
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435140, 4352523, 43525231, 43525233, 4352529, 435440, 435145, 435472, 536 232, 536 231, 536 237, C12P 746, C12P 700, C12N 1574, C12N 1500
Patent
active
061597384
ABSTRACT:
A fermentation process for producing succinic acid is provided comprising selecting a bacterial strain that does not produce succinic acid in high yield, disrupting the normal regulation of sugar metabolism of said bacterial strain, and combining the mutant bacterial strain and selected sugar in anaerobic conditions to facilitate production of succinic acid. Also provided is a method for changing low yield succinic acid producing bacteria to high yield succinic acid producing bacteria comprising selecting a bacterial strain having a phosphotransferase system and altering the phosphotransferase system so as to allow the bacterial strain to simultaneously metabolize different sugars.
REFERENCES:
Postma et al., Phosphoenolpyruvate Carbohydrate Phosphotransferase Systems of Bacteria, Micro. Rev. 57(3): 543-594, Sep. 1993.
Chatterjee Ranjini
Donnelly Mark I.
Sanville-Millard Cynthia
Hutson Richard
Prouty Rebecca E.
University of Chicago
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