Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-10-16
2011-12-20
Strzelecka, Teresa E (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023100, C536S024300
Reexamination Certificate
active
08080377
ABSTRACT:
The present invention relates to a method for confirming the exposure on chrysene using a DNA fragment whose expression is increased or decreased specifically when it is exposed to chrysene. The method of the present invention is effective in determination of risk by chrysene and monitoring the chrysene exposure, so that it can be effectively used as a tool for examining the mechanism of chrysene induced toxicity.
REFERENCES:
patent: 10-2005-0075134 (2005-07-01), None
Castorena-Torres, F. et al., Toxicology in Vitro, vol. 22, pp. 411-421 (2008).
Courter, L. A. et al., Cancer Lett., vol. 265, pp. 135-147 (2008).
Genbank Accession No. NM—000499, revision history, downlaoded May 6, 2011.
Elovaara et al. (2006). “Polycyclic Aromatic Hydrocarbon (PAH) Metabolizing Enzyme Activities in Human Lung, and Their Inducibility by Exposure to Naphthalene, Phenanthrene, Pyrene, Chrysene, and Benzo(a)Pyrene as Shown in the Rat Lung and Liver.” Arch. Toxicol., 81:169-182.
Bultelle et al. (2002). “Identification of Differentially Expressed Genes inDreissena polymorphaExposed to Contaminants.” Marine Environmental Research, 54:385-389.
Jeon Hee-Kyung
Kim Youn-Jung
Ryu Jae-Chun
Song Mi-Kyung
Greenlee Sullivan P.C.
Korea Institute of Science and Technology
Strzelecka Teresa E
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