Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2004-09-23
2010-11-16
Staples, Mark (Department: 1637)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C536S024330
Reexamination Certificate
active
07833757
ABSTRACT:
The invention relates to a method for conducting non-invasive early detection of colon cancer and/or of colon cancer precursor cells, by using primers with which mutation analyses can be carried out in selected regions of genes APC, K-ras, β-catenin and B-raf. The invention also relates to a kit containing said primers, and to the use of these primers and of the kit for analyzing mutations, particularly for conducting the early detection of colon cancer and/or of colon cancer precursory cells.
REFERENCES:
patent: 6114124 (2000-09-01), Albertsen et al.
patent: 6586177 (2003-07-01), Shuber
patent: 2002/0086386 (2002-07-01), Kamb et al.
patent: 197 36 691 (1999-02-01), None
patent: 2327497 (1999-01-01), None
patent: WO 98 58081 (1998-12-01), None
patent: 99/04037 (1999-01-01), None
patent: 01/18252 (2001-03-01), None
patent: WO 01 18252 (2001-03-01), None
patent: WO 01 73002 (2001-10-01), None
Salahshor et al., Colorectal Cancer With and Without Microsatellite Instability Involves Different Genes, Genes, Chromosomes & Cancer 26:247-252 (1999).
Coste et al., Somatic mutations of the b-catenin gene are frequent in mouse and human hepatocellular carcinomas, Proc. Natl. Acad. Sci. USA vol. 95, pp. 8847-8851, Jul. 1998.
Nollet et al., Genomic Organization of the Human b-Catenin Gene (CTNNB1),Genomics 32, 413-424 (1996), Article No. 0136.
Ikawa et al., B-raf, a New Member of the raf Family, Is Activated by DNA Rearrangement, Molecular and Cellular Biology, Jun. 1988, p. 2651-2654 vol. 8, No. 6.
Davies et al., Mutations of the BRAF gene in human cancer, Nature, vol. 417, Jun. 27, 2002, pp. 949-954.
Buck et al., Research Report Design Strategies and Performance of Custom DNA Sequencing Primers, BioTechniques vol. 27, No. 3, pp. 528-536, (1999).
Stratagene, 1998 catalog, p. 39.
Gerry et al., Universal DNA Microarray Method for Multiplex Detection of Low Abundance Point Mutations, J. Mol. Biol. (1999) 292, 251-262.
Baba et al., Review, Analysis of disease-causing genes and DNA-based drugs by capillary electrophoresis Towards DNA diagnosis and gene therapy for human diseases, Journal of Chromatography B, 687 (1996) 271-302.
McCormick, Signalling networks that cause cancer, Trends in Genetics, Millenium issue, 1999, pp. M53- M56.
Stratagene, 1988 catalog, p. 39.
Scholtka and Steinberg et al., A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans, Cancer Epidemiology 33 (2009) 123-129.
Salahshor Sima et al.; “Colorectal Cancer With and Without Microsatellite Instability Involved Different Genes”; Genes Chromosomes and Cancer; vol. 26, No. 3, Nov. 1999, pp. 247-252.
Rajagopalan H et al.; “RAF/RAS Oncogenes and Mismatch-Repair Status”; Nature, MacMillan Journals Ltd.; London; vol. 418, No. 20, Aug. 2002; p. 934.
Davies H et al.; “Mutations of the BRAF Gene in Human Cancer”; Nature, MacMillan Journals Ltd., London; vol. 417, No. 6892; Jun. 27, 2002, pp. 949-954.
Yuen S T et al.; “Similarity of the Phenotypic Patterns Associated with BRAF and KRAS Mutations in Colorectal Neoplasia”; Cancer Research, American Association for Cancer Research, Baltimore, MD, vol. 62, No. 22, Nov. 15, 2002, pp. 6451-6455.
Prix Lothar et al.; “Diagnostic Biochip Array for Fast and Sensitive Detection of K-ras Mutations in Stool”; Clinical Chemistry; vol. 48, No. 3, Mar. 2002, pp. 428-435.
Dong Seung Myung et al.; “Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets”; Journal of the National Cancer Institute; vol. 93, No. 11, Jun. 6, 2001, pp. 858-865.
Scholtka Bettina
Steinberg Pablo
Londa Bruce S.
Norris McLaughlin & Marcus PA
Staples Mark
Universitael Posidam
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