Method for concentrating and purifying antihemophilic factor or

Details Method for concentrating and purifying antihemophilic factor or Method for concentrating and purifying antihemophilic factor or

1980-01-18

1981-11-24

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3514

Patent

active

043024459

ABSTRACT:
A method is disclosed for concentrating and purifying antihemophilic factor (AHF or Factor VIII), a cryoprecipitate is collected from frozen human plasma and cold washed with pyrogen-free distilled water or water saline. The washed cryoprecipitate is extracted with pyrogen-free distilled water, the prothrombin complex is removed and the fibrinogen is precipitated. The remaining purified solution is ultrafiltered to form a highly concentrated Factor VIII solution.

REFERENCES:
patent: 4104266 (1978-08-01), Wickerhauser
patent: 4170639 (1979-10-01), Liu et al.
patent: 4188318 (1980-02-01), Shanbrom
Wickerhauser et al. -Vox Sanguinis, vol. 35 (1978) pp. 18-31.

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