Method for clustering sequences in groups

Details Method for clustering sequences in groups Method for clustering sequences in groups

2000-06-16

2001-10-16

Allen, Marianne P. (Department: 1631)

Data processing: database and file management or data structures

Database design

Data structure types

C702S020000, C707S793000, C707S793000, C707S793000

Reexamination Certificate

active

06304868

ABSTRACT:

This invention concerns a method of grouping sequences in families.
Large quantities of protein sequence data are generated today in molecular biology. A major problem here is how to group such protein sequence data logically in biological families. Since families are not defined exactly, but instead the diversity of different gene families varies, this involves a problem in data grouping which is not at all trivial.
In the past, biological information could only be of assistance for human experts who would thoroughly research the output of database searching programs and would create a grouping according to families. This method is time-consuming, labor-intensive and not very reproducible.
Therefore, the object of this invention is to find a method with which a large set of protein sequences can be divided into groups fully automatically.
This object is achieved with the features of Patent Claim
1
.


REFERENCES:
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Pearson et al. Improved tools for biological sequence comparison. Proc. Natl. Acad. Sci, Vol. 85(8), pp.2444-8 (1988).*
Harris et al. XP-002091600. “Class X: A Browsing Tool for Protein Sequence Megaclassifications” pp. 554-563 (1993).
XP-002091665. Abstract. “Mega-Classification: discovering motifs in massive datastreams” . Harris et al. (1992).
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