Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Patent
1997-10-01
1999-06-15
Elliott, George C.
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
359368, 252582, C12M 134, G02B 2116, F21V 908
Patent
active
059121653
ABSTRACT:
A method and hardware for chromosome classification by decorrelation statistical analysis to provide color (spectral) karyotypes and to detect chromosomal aberrations. The method and hardware employ a set of N decorrelation matched filters for chromosome classification. The N decorrelation matched filters are dedicated for extracting decorrelated spectral data from chromosome samples painted according to a specific experimental protocol. The N decorrelation matched filters being described by: ##EQU1## where V.sub.ik min equals minimum V.sub.ik over all i, and V.sub.ik max equals maximum V.sub.ik over all i, and wherein N is an integer greater than two.
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Reid et al. Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy. Proc. Natl. Acad. Sci. USA vol. 89 pp. 1388-1392, 1992.
Ben-Yosef Nissim
Buckwald Robert A.
Cabib Dario
Applied Spectral Imaging Ltd
Brusca John S.
Elliott George C.
Friedman Mark M.
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