Method for chlorinating the carboxylic group of .alpha.-aminoaci

Details Method for chlorinating the carboxylic group of .alpha.-aminoaci Method for chlorinating the carboxylic group of .alpha.-aminoaci

1981-05-07

1983-01-18

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465D, C07C 5160

Patent

active

043691463

ABSTRACT:
A method for chlorinating the carboxylic group of .alpha.-aminoacids (e.g. hydroxyphenyl-glycine) is described wherein the aminoacid is suspended in an optionally solvate-forming solvent, treated with an excess of gaseous HCl and then with a chlorinating agent having the general formula [SO.sub.a Cl.sub.2.R.sub.1 R.sub.2 NCHO] (e.g. SO Cl.sub.2.(CH.sub.3).sub.2 NCHO).
A typical compound thus obtained is the dioxane hemisolvate of D(-)2-(p-hydroxyphenyl)glycyl chloride hydrochloride.

REFERENCES:
patent: 3925418 (1975-12-01), Williams et al.
Fieser and Fieser, Advanced Organic Chemistry, Reinhold Publishing Corp., New York (1961) pp. 382-383.

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