Method for chiral inversion of (S)-(+)-and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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Reexamination Certificate

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07999100

ABSTRACT:
A method for chiral inversion of optically pure or optically enriched mixtures of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (I) and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide (II).

REFERENCES:
patent: 5753646 (1998-05-01), Benes et al.
patent: 02/092572 (2002-11-01), None
Benes, Jan, et al., “Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f] azepine-5-carboxamide Derivatives,” Journal of Medicinal Chemistry, 1999, pp. 2582-2587, vol. 42, No. 14, American Chemical Society.
Cid, José, et al., “Synthesis and structure-activity relationship of 2-(aminoalkyl)-3,3a,8,12b-tetrahydro-2H-dibenzocyclohepta[1,2-b]furan derivatives: a novel series of 5-HT2A/2C receptor antagonists,” Bioorganic & Medicinal Chemistry Letters, 2004, pp. 2765-2771, vol. 14, Elsevier Ltd.
Mitsunobu, Oyo, “The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products,” Synthesis, Jan. 1981, pp. 1-28, Georg Thieme Verlag, Stuttgart-New York.
Schütz, H., et al., “The metabolism of 14C-oxcarbazepine in man,” Xenobiotica, 1986, pp. 769-778, vol. 16, No. 8.
Foreign communication from a related counterpart application—International Search Report, PCT/GB2005/002744, Oct. 20, 2005, 2 pgs.
Foreign communication from a related counterpart application—International Preliminary Report on Patentability, PCT/GB2005/002744, Jan. 16, 2007, 7 pgs.

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