Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-02
1999-10-26
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 792, 436514, 436516, 436813, 530350, 530403, 530413, 530826, G01N 33574
Patent
active
059726296
ABSTRACT:
This invention features methods for characterizing antigenic reactivity of biological samples by contacting a biological sample with two or a plurality of monoclonal receptor molecules raised to an immunogen containing a polypeptide of about 7 to about 40 amino acid residues and comparing the ensuing reaction pattern with a pattern generated with a known biological sample.
REFERENCES:
Paul. Fundamental Immunology. N.Y., Raven Press, 1984. pp. 626-631.
MacLean et al, "Antigenic Heterogeneity of Human Colorectal Cancer Cell Lines Analyzed by a Panel of Monoclonal Antibodies. I. Heterogeneous Expression of Ia-Like and HLA-Like Antigenic Determinants", Journal of the National Cancer Institute, vol. 69, No. 2 (Aug. 1982), pp. 357-364. RC261.A1U5.
Platt et al, "A Computerised Elisa System for the Determination of Total and Antigen-Specific Immunoglobulins in Serum and Secretions", Journal of Immunossay, vol. 2, No. 1 (1981), pp. 59-74. Abstract Only.
Hand et al, "Definition of Antigenic Heterogeneity and Modulation among Human Mammary Carcinoma Cell Populations Using Monoclonal Antibodies to Tumor-Associated Antigens", Cancer Research, vol. 43, No. 2 (Feb 1983), pp. 728-735. RC261.A1C2.
Jacquet et al, "A Microquantitative Method for Investigating the Interaction Between Labeled Lectins and the Surface Membranes of Human Lymphocytes Using a Semi-automatic Harvesting Machine", Experientia, vol. 39, No. 1 (Jan.15, 1983) pp. 123-126.
Genta et al, "Evaluation of the Titertek Multiskan for Determining Minimal Inhibitory Concentration Endpoints", Antimicrobial Agents and Chemotherapy, vol. 22, No. 1 (Jul. 1982) pp. 151-153.
Fitting Thomas
Holmes Emily
Stucker Jeffrey
The Scripps Research Institute
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