Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;...
Reexamination Certificate
2005-05-17
2005-05-17
Haff, David M. (Department: 1651)
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
C435S176000, C435S177000, C435S178000, C435S179000, C435S180000, C435S182000, C435S243000, C435S325000, C435S395000
Reexamination Certificate
active
06893850
ABSTRACT:
The present invention provides a masking system for selectively applying cells to predetermined regions of a surface. A mask is positioned adjacent to a surface to cover some portions of the surface while allowing other portions of the surface to remain uncovered. Cells then are applied to uncovered portions of the surface and the mask removed. Alternatively, a cell-adhesion promoter is applied to uncovered portions of the surface, and then cells are applied to the surface before or after removal of the mask from the surface. The masking system can be pre-coated, at least on those surfaces which will come into contact with cells, with a cell-adhesion inhibitor to resist absorption of cells and thereby avoid cell damage when the mask is removed (if cells are deposited prior to removal of the mask). A polymeric elastomeric mask that comes into cohesive-conformal contact with a surface to be patterned can be used.
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Duffy David C.
Jackman Rebecca J.
Kane Ravi
Ostuni Emanuele
Whitesides George M.
Haff David M.
President and Fellows of Harvard College
Ware Deborah K.
Wolf Greenfield & Sacks P.C.
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