Method for causing skin lightening

Drug – bio-affecting and body treating compositions – Bleach for live hair or skin

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424401, 4241951, 514283, 206287, H03K 301

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active

061104485

ABSTRACT:
A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof, or effective .alpha..sub.2 -antagonists, skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark. The composition may include a skin exfoliant.

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Morishita, F.; "Responses of the Melanophores of the Medaka, Oryzias Latipes, To Adrenergic Drugs: Evidence for Involvement of Alpha.sub.2, Adrenergic Receptors Mediating Melanin Aggregation", Comp. Biochem. Physiol., 88C(1):69-74, 1987.
Abstract, Database WPI, Week 9549, Derwent Publications Ltd., London, GB; AN 379974, XP002094296 & JP 07 258068 A (KA0) Oct. 9, 1995.

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