Method for catalytic preparation of hydromorphone and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C546S044000, C546S046000

Reexamination Certificate

active

07399859

ABSTRACT:
The present invention generally relates to catalysts of formula (III)in-line-formulae description="In-line Formulae" end="lead"?[M(P(Ra)(Rb)N(Rc)(Rd))2Xn]mYpin-line-formulae description="In-line Formulae" end="tail"?that selectively convert morphine/codeine to hydromorphone/hydrocodone, and methods of use thereof.

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Kashiwabara, et al., “Chiral recognition in catalytic hydrogenation of α-acrylaminoacrylic acids by cationic rhodium (l) complexes of chiral aminophosphines derived from (R,R)-1,2-cyclohexanediamine or (R)-1,2-propanediamine”J. Bull. Chem. Soc. Jpn.1980, 53, 2275.
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