Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2003-05-20
2009-10-27
Aeder, Sean E (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07608403
ABSTRACT:
Described is a method for cancer detection, progression analysis and malign tumor prognosis based on the study of metabolic markers of the cell. The method consists in using the study of the protein expression of the bioenergetic function of the mitochondrion, such as the beta-catalytic subunit of the H-ATP synthase, in relation to structural proteins and mitochondrial respiration, such as hsp 60 and cytochrome oxidase subunits I and IV respectively, and said mitochondrial bioenergetic index, (ratio of beta-ATPasa/hsp60; beta-ATPasa/COX I; beta-ATPasa/COX IV) which relates to the cellular protein expression of the glycolytic pathway, such as glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase M, in order to generate the bioenergetic index of the cell.
REFERENCES:
Klouwen and Appelman (Feb. 1967, Cancer Research, 27(1):255-260).
Klouwen and Appelman (Cancer Research, Feb. 1967, 27(1):255-260).
Moser et al (PNAS, Jun. 2001, 98(12):6656-6661).
Appelman (Cancer Research, Feb. 1967, 27(1):255-260).
Cuezva et al (Cancer Research, Nov. 2002, 62:6674-6681).
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Aeder Sean E
Fay Kaplun & Marcin LLP
Universidad Autonoma de Madrid
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