Method for calculating blood flow using freely diffusible inert

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A61B 502

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046102582

ABSTRACT:
A simplified method of determining tissue blood flow such as cerebral blood flow is provided by calculating the partial derivatives with respect to flow rate constant (k) and partition coefficient (.lambda.) of the sum of errors squared for calculated tissue concentration of a diffusible inert gas such as xenon minus measured tissue concentration of xenon based on CT numbers.

REFERENCES:
Haughton, V. et al, "Clinical Cerebral BF Measurement with Inhaled Xenon and CT", AJR 134: 281-283, 1978.
Kelz, F. et al, "Computed Tomographic Measurement of the Xenon Brain-Blood Partition Coefficient and Implications for Regional Cerebral BF", Radiology 127: 385-392 1978.
Gur, D. et al, "Progress in Cerebrovascular Disease: Local Cerebral BF by Xenon Enhanced CT," Stroke 13: 750-758, 1982.
Forsythe, G. E. et al, "Computer Methods for Mathematical Computations," Prentice Hall, Inc. (no date available).
Gur, D. et al, "Xenon and Iodine Enhanced Cerebral CT: A Closer Look," Strohe 12: 573-578, 1981.
De Fontaine, D. L. et al, "A Fast Non-Linear Least Squares Method for the Calculation of Relaxation Times," Jrnl. of Mag. Resonance, 18: 276-281 (1975).
Haughton, V. M. et al, "A Clinical Evaluation of Xenon Enhancement for Computed Tomography", Investigative Radiology, Supp. to vol. 15, No. 6, 5160-5163.
Palla, R. S. et al, "Regional Cerebral BF Measurements Using Stable Xenon Enhanced CT: A Theoretical and Exp. Evalution," Jrnl. of Comp. Asstd. Tomog. 8(4): 619-630, Aug. 1984.
Wagner, P. D. et al, "Measurement of Continuous Distributions of Ventilation-Perfusion Ratios: Theory" , Jrnl. Appl. Physiology, vol. 36, No. 5, May 1974, pp. 588-599.
Fuller, G. et al, "Analytic Geometry and Calculus," Ch. 18: Partial Differentiation Section 18-13 Maxima and Minima, pp. 518-522.

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