Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1997-06-16
1999-11-16
Weber, Jon P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530408, 530409, 436 89, A61K 3801, C07K 100, G01N 3300
Patent
active
059860715
ABSTRACT:
A method for C-Terminal degradation of peptides and proteins involves forming a thiohydantoin derivative of the C-Terminal amino acid and then cleaving the derivatized amino acid by reaction with methoxide or methiolate ions.
REFERENCES:
patent: 5059540 (1991-10-01), Bailey
patent: 5432092 (1995-07-01), Bailey et al.
Solomans, T. "Organic Chemistry", 2nd edition (1980) (Wiley: New York) pp. 187-191.
Carey et al. "Advanced Organic Chemistry", 2nd edition (1984) (Plenum Press: New York) pp. 263-271.
Streitwieser et al. "Introduction to Organic Chemistry", 2nd edition, (1981) (Macmillan: New York) pp. 164-170.
Sayre, L. "Metal ion catalysis of amide hydrolysis," J. Am. Chem. Soc. (1986) 108: 1632-35.
Fersht, A. "Acyl-transfer of amides and esters with alcohols and thiols. A reference system for the serine and cysteine proteinases. Concerning the N protonation of amides and amide-imidate equilibria," J. Am. Chem. Soc. (1971) 93(14): 3504-15.
Graham Kenneth S.
Shively John E.
City of Hope
Hanley Susan
Weber Jon P.
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