Method for base sequencing and biologically active nucleic...

Details Method for base sequencing and biologically active nucleic... Method for base sequencing and biologically active nucleic...

2008-05-20

2008-05-20

Riley, Jezia (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100, C536S024300, C536S024330, C435S091100, C435S091200

Reexamination Certificate

active

10432991

ABSTRACT:
Aptamers are nucleic acids and similar molecules, such as peptide-nucleic acids, that specifically bind to a ligand such as a protein or peptide. The present invention provides aptamers comprising at least one base capable of base pairing and different from the standard Watson-Crick bases. The present invention also relates to a method for preparation of such aptamers and to methods for sequencing nucleic acids that comprise at least one base capable of base pairing and different from the standard Watson-Crick bases.

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Tuerk, C., et al. Science, American Association for the Advancement of Science, US, vol. 249, Aug. 3, 1990, pp. 505-510.

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