Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1998-11-12
2000-11-28
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514540, 514557, 514653, A61K 3122
Patent
active
061536474
ABSTRACT:
A method for treating medical patients suffering from cardiac trauma by co-administering pyruvate with a .beta.-adrenergic agonist. This method for treating cardiac trauma, such as ischemic reperfusion injury and heart failure, augments the inotropic effects of .beta.-adrenergic agents. Typical .beta.-adrenergic agonists are epinephrine, norepinephrine, dobutamine, and isoproterenol. The amount of .beta.-adrenergic agonist necessary to achieve a 50 percent increase of cardiac power is diminished five-fold when co-administered with pyruvate. Since high concentrations of agonists have many detrimental and hazardous side effects in patients, this invention would have important applications in the treatment of patients with cardiac trauma such as ischemia reperfusion injury.
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Tejero-Taldo et al., Journal of Mol. and Cell. Cardiol., (1997), vol. 29, No. 6, pp. A202.
Tejero-Taldo et al., Journal of Mol. and Cell. Cardiol., (1998), vol. 30, No. 11, pp. 2327-2339.
Tejero-Taldo et al., FASEB Journal, (1996), vol. 10, No. 3, pp. A320.
Caffrey James L.
Mallet Robert T.
Tejero-Taldo Maria Isabel
Cintins Marianne M.
Delacroix-Muirheid C.
Gunter Jr. Charles D.
Kaulkner Kevin M.
My-Tech, Inc.
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