Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Patent
1987-12-29
1990-06-26
Teskin, Robin L.
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
424 858, 424 86, 424 88, 435 29, 4352402, 530380, 530386, 530387, 530388, 436513, A61K 3900, C12N 1500
Patent
active
049370715
ABSTRACT:
A method for enhancing the ability for humoral immune response in a mammal comprising: exposing lymphocytes histocompatible with the lymphocytes of said mammal to the presence of delta-immunoglobulin at a concentration higher than that at which said lymphocytes would have been exposed while in the lymph or bloodstream of said mammal; and introducing said lymphocytes to the bloodstream or lymph of said mammal.
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Perera et al, Eur J Imm, vol. 12, pp. 540-546, 1982, "Immature B Cells in Fetal Development and Immonostructures of IgM, FgCr, IgA and IgD Punctuation In Vitro Using Epstein-Barr Virus Activation".
Finkelman et al, I Imm, vol. 129(2), Aug. 1987, pp. 638-646, "Polyclonal Activaton of the Murine Immune System by An Antibody to IgD".
Cuchens et al, J Imm, vol. 121(6), Dec. 1978, pp. 2257-2262, "The Effects of Anti-IgD on Serum Immunoglobulins, Antibody Production . . . ".
Xue et al, J Exp Mol, vol. 159, Jan. 1987, pp. 103-113, "Physiology of IgD IV Enhancement of Antibody Production in Mice Bearing IgD Secretory Plasmacytomye".
Muul et al, Eur J Imm, vol. 13, pp. 900-905, 1983, "Polyclonal Activation of the Murine Immune System by an Antibody to IgD".
Khorobrykh et al, Biol. Abstr. 1978, vol. 66 (10), No. 58766 "Effect on Antisera to Aggregated Mouse Immunoglobulin on the Population of Lymphoid and Hemopoietic Cells".
Sjoberg, O., "Presence of Receptors for IgD on Human T and Non-T Lymphocytes"; Scand. J. Immunol. 11:377-382, 1980.
Cioco Richard F.
Thorbecke G. Jeanette
New York University
Teskin Robin L.
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