Method for augmenting fetal hemoglobin

Details Method for augmenting fetal hemoglobin Method for augmenting fetal hemoglobin

1986-10-10

1989-04-18

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514 2, 514 3, 514 4, 514561, 514815, A61K 3119, A61K 31195, A61K 3126

Patent

active

048228214

ABSTRACT:
A method is provided for inhibiting the .gamma. to .beta.-globin switching in subjects afflicted with .beta.-globin disorders. The method is particularly adapted for ameliorating the clinical symptoms of sickle cell anemia by periodically introducing into the bloodstream of the subject prior to natural completion of the switching process .alpha.-amino-n-butyric acid, butyric acid, isomers or salts thereof, insulin, histone deacetylase inhibitors, or mixtures thereof.

REFERENCES:
Karlsson-Ann. Rev. Biochem 1985, 54 1071-1101.
"Development of Therapeutic Agents for Sickle Cell Disease", Rosa et al., North-Holland Pub. Co. Amsterdam-N.Y.-Oxyford, pp. 129-137.

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