Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-05-19
2000-02-01
Wallenhorst, Maureen M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 436 63, 436 86, 436 87, 4241981, A61K 3800
Patent
active
060203102
ABSTRACT:
A novel relationship between pancreatico-biliary secretion and autistic syndrome is disclosed. This relationship enables a novel therapy for the treatment of the symptoms of autistic syndromes, comprising the administration of a therapeutically effective, preferably intravenous, dose of secretin to an individual with autistic syndrome. The relationship further enables a differential diagnosis for autistic syndrome, comprising an analysis of an individual's blood and/or intestinal tissue for the presence of secretin and comparison of the level of secretin to known norms.
REFERENCES:
patent: 3940480 (1976-02-01), Seunaga
patent: 3987014 (1976-10-01), Guiducci
patent: 4086220 (1978-04-01), Schlatter
patent: 4098779 (1978-07-01), Konig
patent: 4302448 (1981-11-01), Bickel
patent: 4533494 (1985-08-01), Uchiyama
patent: 4711847 (1987-12-01), Konig
patent: 4778794 (1988-10-01), Naruse et al.
patent: 4806336 (1989-02-01), Carlquist et al.
patent: 4920122 (1990-04-01), Naruse et al.
patent: 4994467 (1991-02-01), Zimmerman
patent: 5008251 (1991-04-01), Gruber
patent: 5094837 (1992-03-01), Bis
patent: 5225407 (1993-07-01), Oakley et al.
patent: 5527825 (1996-06-01), Karson et al.
patent: 5686311 (1997-11-01), Shaw
Schopler, Reichler, DeVellis, Daly, "Toward Objective Classification of Childhood Austism: Childhood Autism Rating Scale (CARS)", J. of Autism & Dev. Disorders 10(1):1980, pp. 91-103.
Karelson, Laasik, Sillard, "Regulation of Adenylate Cyclase by Galanin, Neuropeitide Y, Secretin and Vasoactive Intestinal Polypeptide in Rat Frontal Cortex,Hippocampus and Hypothalamus", Neuropeptides 28;1995, pp. 21-28.
vanCalker, Muller, Hamprecht, "Regulation by secretin, vasoactive intestinal peptide, and somatostatin of cyclic AMP accumulation in cultured brain cells", Proc. Natl. Acad. Sci. USA 77(11):1980, pp. 6907-6911.
McGill, Basavappa, Gettys, Fitz, "Secretin activates C1.sup.- channels in bile duct epithelial cells through a cAMP-dependent mechanism", Am. J. Physiology, 1994; 266:C731-6.
Leiter, Chey, Kopin, "Secretin", Gut peptides: Biochemistry and Physiology edited by Walsh and Dockray, Raven Press, Ltd., New York, 1994:147-93.
Fara, Madden, "Effect of secretin and cholecystokinin on small intestinal blood flow distribution," Am. J. Physiology, 1975; 229(5):1365-70.
Dollinger, Berz,Raptis, vonUexkull, Goebell, "Effects of Secretin and Cholecystokinin on Motor Activity of Human Jejunum", Digestion 12:1975, pp. 9-16.
Horvath, Stefanatos,Sokolski, Wachtel, Nabors, Tildon, "Improved social and language skills after secretin administration in patients with autistic spectrum disorders", J. Assoc. for Academic Minority Physicians 9(1):1998, pp. 9-15.
Raymond, Bauman, Kemper, "Hippocampus in autism: a Golgi analysis", Acta Neuropathologica, 1996; 91(1):117-9.
Charlton, O'Donohue, Miller, Jacobowitz, "Secretin immunoreactivity in rat and pig brain", Peptides, 1981; 2 suppl 1:45-9.
Fremeau, Korman, Moody, "Secretin stimulates cyclic AMP formation in the rat brain", Journal of Neurochemistry, 1986; 46(6):1947-55.
Fremeau, Jensen, Charlton, Miller, O'Donohue, Moody, "Secretin: specific binding to rat brain membranes", Journal of Neuroscience, 1983; 3(8):162-05.
Kimura, Mitsugi, Arita, Akema, Yoshida, "Effects of preoptic injections of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized estrogen-primed rats", Brain Research, 1987; 410(2):315-22.
Bauman, Kemper, "Histoanatomic observations of the brain in early infantile autism", Neurology, 1985; 35(6):866-74.
Minshew, "In vivo brain chemistry of autism", magnetic resonance spectroscopy studies in The Neurology of Autisum, Bauman and Kemper (editors), The Johns Hopkins Press, Baltimore, 1994, 1994:66-85.
Baumann, Kemper, "Neuroanatomic observations of the brain in autism" in The Neurobiology of Autism, Bauman and Kemper (editors), The Johns Hopkins Press, Baltimore, 1994, 1994:119-45.
Hoon, Reiss, "The mesial-temporal lobe and autism: case report and review" [Review], Developmental Medicine & Child Neurology, 1992; 34(3):252-9.
Bachevalier, Merjanian, "The contribution of medial temporal lobe structures in infantile autism: a neurobehavioral study in primates", in The Neurobiology of Autism, Bauman and Kemper (editors), The Johns Hopkins Press, Baltimore, 1994, 1994:146-69.
Dawson, Klinger, Panagiotides, Lewy, Castelloe, "Subgroups of autistic children based on social behavior display distinct patterns of brain activity", Journal of Abnormal Child Psychology, 1995; 23(5):569-83.
George, Costa, Kouris, Ring, Ell, "Cerebral blood flow abnormalities in adults with infantile autism", Journal of Nervous & Mental Disease, 1992; 180(7):413-7.
Olsson, Steffenburg, Gillberg, "Epilepsy in autism and autisticlike conditions: a population-based study", Archives of Neurology, 1988; 45(6):666-8.
Anderson, Freedman, Cohen, et al, "Whole blood serotonin in autistic and normal subjects", J. Child Psychology & Psychiatry & Allied Disciplines, 1987; 28(6):885-900.
Garnier, Comoy, Barthelemy, et al., "Dopamine-beta-hydroxylase (DBH) and homovanillic acid (HVA) in autistic children", J. Autism & Developmental Disorders, 1988; 16(1):23-9.
Bouvard, Leboyer, Launay, et al, "Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study", Psychiatry Research, 1995; 58(3):191-201.
El-Salhy, Abou-el-Ela, Falkmer, Grimelius, Wilander, "Immunohistochemical evidence of gastro-entero-pancreatic neurohormonal peptides of vertebrate type in the nervous system of the larva of a dipteran insect, the Hoverfly, Eristalis Aeneus", Regulatory Peptides 1:1980, pp. 187-204.
McDougle, Price, Volkmar, "Recent advances in the pharmacotherapy of autism and related conditions", Child & Adolescent Psych. Clinics of N. Am., 1994; 3(1):71-89.
Patel, Kong, Sreedharan, "Molecular cloning and expression of a human secretin receptor", Molecular Pharmacology, 1995; 47(3):467-73.
Lenzen, Alpini, Tavoloni, "Secretin stimulates bile ductular secretory activity through the cAMP system", American Journal of Physiology, 1992; 263(4 pt 1):G527-32.
Pollack,Wood, Solomon, "Effect of secretin on growth of stomach, small intestine, and pancreas of developing rats", Digestive Diseases & Sciences, 1990; 35(6):749-58.
Lebenthal, Clark, "Immunoglobin concentrations in the duodenal fluids of infants and children" II. The Effect of pancreozymin and secretin, Am. J. Gastroenterology, 1981; 75(6):436-9.
Lawrence, Bryant, Roberts, Barrowman, "Effect of secretin on intestinal lymph flow and composition in the rat", Quarterly J. Experimental Physiology, 1981; 66(3):297-305.
Ohta, Funakoshi, Kawasaki, Itoh, "Tissue-specific expression of the rat secretin precursor gene", Biochemical & Biophysical Research Communications 183(2):1982, pp. 390-395.
Itoh, Furuya, Ozaki, Ohta, Kawasaki, "The secretin precursor gene: structure of the coding region and expression in the brain", J. Biological Chemistry, 1991; 266(19):12595-8.
Redgate, Deupree, Axelrod, "Interaction of neuropeptides and biogenic amines on cyclic adenosine monophosphate accumulation in hypothalamic nuclei", Brain Research, 1986; 365(1):61-9.
Usdin, Bonner, Mezey, "Two receptors for vasoactive intestinal polypeptide with similar specificity and complementary distributions", Endocrinology, 1994; 135(6):2662-80.
Cook et al., "The Serotonin System in Autism", Current Opinion in Pediatrics, 8:348-354, (1996).
Harteveld et al., "Autism--Role of Drug Treatment and a Guide to its Use", CNS Drugs, 8(3):227-236, (1997).
Horvath et al., "Improved Social and Language Skills After Secretin Administration in Patients with Autistic Spectrum Disorders", J. Assoc. Acad. Minority Physicians, 9(1):9-15, (1998).
Piven, "The Biological Basis of Autism", Curr. Op. Neurobiol., 7:708-712, (1997).
Rapin et al., "Neurobiology of Autism", Annals of Neurology, 43:7-14, (1998).
Ritvo et al., "A Medical Model of Autism:Etiology, Pathology and Treatment", Pediatric Annals, 13(4):298-305, (1984).
Wickelgren, "Tracking Insulin to the Mind", Sc
Beck Victoria
Horvath Karoly
Repligen Corporation
Wallenhorst Maureen M.
LandOfFree
Method for assisting in differential diagnosis and treatment of does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for assisting in differential diagnosis and treatment of , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for assisting in differential diagnosis and treatment of will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-937577