Method for assessing trait anxiety by determining...

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Reexamination Certificate

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Reexamination Certificate

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07494783

ABSTRACT:
The invention provides methods/kits for assessing levels of trait or state anxiety in a subject by comparing genotypes and/or expression patterns at the ACHE, PON1 and/or BChE genes to the genotype and/or expression pattern of the genes in a reference population whose genotype and/or expression pattern of the genes is known or by correlating AChE levels activity to those of PON.

REFERENCES:
patent: 4683202 (1987-07-01), Mullis
patent: 6300063 (2001-10-01), Lipshutz et al.
patent: 6746850 (2004-06-01), Feaster et al.
patent: 2002/0009730 (2002-01-01), Chenchick et al.
patent: 2003/0036632 (2003-02-01), Soreq et al.
patent: 2003/0082548 (2003-05-01), Shu et al.
patent: 2003/0162207 (2003-08-01), Comings et al.
patent: 2003/0175210 (2003-09-01), Leyland-Jones
patent: 0717113 (1996-06-01), None
patent: 0730663 (1996-09-01), None
patent: WO 92/15712 (1992-09-01), None
patent: WO 97/02102 (1997-01-01), None
patent: WO 97/04127 (1997-02-01), None
patent: WO 97/29212 (1997-08-01), None
patent: WO 2004/029290 (2004-04-01), None
patent: WO 2004/029290 (2004-04-01), None
Sklan E. et al. Acetylcholinesterase/Paraoxonase Genotype and Expression Predict Anxiety Scores . . . PNAS 101(15)5512-17, Apr. 13, 2004.
Mathew R. et al. True and Pseudo Cholinesterases in Depression. American J Psychiatry 139(1)125-127, 1982.
Modai I. et al. Serum Pseudocholinesterase in State Anxiety. J Clinical Psychiatry 48(5)204-6, May 1987.
Abrams et al. “Comprehensive Detection of Single Base Changes in Human Genomic DNA Using Denaturing Gradient Gel Electrophoresis and A GC Clamp”, Genomics, 7: 463-475, 1990.
Abravaya et al. “Detection of Point Mutations With A Modified Ligase Chain Reaction (Gap-LCR)”, Nucleic Acids Research, 23(4); 675-682, 1995.
Abravaya et al. “Molecular Beacons as Diagnostic Tools: Technology and Applications”, Clinical and Chemical Laboratory Medicine, 41(4): 468-474, 2003.
Akhmedova et al. “Paraoxonase 1 Met-Leu 54 Polymorphism Is Associated With Parkinson's Disease”, Journal of Neurological Sciences, 184(2); 179-182, 2001. p. 180, col. 1-2, § 2, p. 181, col. 1-2, § 3, Abstract.
Akula et al. “Utility and Accuracy of Template-Directed Dye-Terminator Incorporation With Fluorescence-Polarization Detection for Genotyping Single Nucleotide Polymorphisms”, BioTechniques, 32(5): 1072-1078, 2002.
Anisman et al. “Cytokines, Stress and Depressive Illness: Brain-Immune Interactions”, Annal of Medicine, 35: 2-11, 2003.
Aviram et al. “Paraoxonase Inhibits High-Density Lipoprotein Oxidation and Preserves Its Functions”, Journal of Clinical Investigation, 101(8): 1581-1590, 1998.
Balciuniene et al. “Investigation of the Functional Effect of Monoamine Oxidase Polymorphisms in Human Brain”, Human Genetics, 110: 1-7, 2002.
Barany “Genetic Disease Detection and DNA Amplification Using Cloned Thermostable Ligase”, Proc. Natl. Acad. Sci. USA, 88: 189-193, 1991.
Bartels et al. “Mutation at Codon 322 in the Human Acetylcholinesterase (ACHE) Gene Accounts for YT Blood Group Polymorphism”, American Journal of Human Genetics, 52(5): 928-936, 1993.
Beaudet et al. “Homogeneous Assays for Single-Nucleotide Polymorphism Typing Using AlphaScreen”, Genome Research, 11: 600-608, 2001.
Bell et al. “SNPStream® UHT: Ultra-High Throughput SNP Genotyping for Pharmacogenomics and Drug Discovery”, BioTechniques Supplements, 32: S70-S77, 2002.
Bernik et al. “Pharmacological Stimulation of the Cholinergic Antiinflammatory Pathway”, Journal of Experimental Medicine, 195(6): 781-788, 2002.
Birikh et al. “Interaction of ‘Readthrough’ Acetylcholinesterase With RACK1 and PKCβII Correlates With Intensified Fear-Induced Conflict Behavior”, Proc. Natl. Acad. Sci. USA, 100(1): 283-288, 2003.
Blatter Garin et al. “Paraoxonase Polymorphism Met-Leu54 Is Associated With Modified Serum Concentrations of the Enzyme”, Journal of clinical Investigation, 99(1): 62-66, 1997.
Blatter Garin et al. “Paraoxonase Polymorphism Met-Leu54 Is Associated With Modified Serum Concentrations of the Enzyme”, Journal of Clinical Investigations, 99(1): 62-66, 1997. p. 63, col. 1, Lines 10-65, Abstract.
Blumenthal et al. “Contribution of Job Strain, Job Status and Marital Status to Laboratory and Ambulatory Blood Pressure in Patients With Mild Hypertension”, Journal of Psychosomatic Research, 39(2): 133-144, 1995.
Børresen et al. “Constant Denaturant Gel Electrophoresis as A Rapid Screening Technique for P53 Mutations”, Proc. Natl. Acad. Sci. USA, 88: 8405-8409, 1991.
Bouchard et al. “Aims, Design, and Measurement Protocol”, Medicine and Science in Sports and Exercise, 27: 721-729, 1995.
Brenner et al. “The role of Readthrough Acetylcholinesterase in the Pathophysiology of Myasthenia Gravis”, The FASEB Journal, 17: 214-222, 2003.
Brophy et al. “Effects of 5′ Regulatory-Region Polymorphisms on Paraoxonase-Gene (PON1) Expression”, American Journal of Human Genetics, 68: 1428-1436, 2001.
Carmine et al. “Further Evidence for An Association of the Paraoxonase 1 (PON1) Met-54 Allele With Parkinson' Disease”, Movement Disorders, 17(4): 764-766, 2002. p. 765, Table 1, col. 1, Line 34-col. 2, Line 29.
Cashman et al. “Population Distribution of Human Flavin-Containing Monooxygenase Form 3: Gene Polymorphisms”, Drug Metabolism and Disposition, 29(12): 1629-1637, 2001.
Cohen et al. “Endotoxin-Induced Changes in Human Working and Declarative Memory Associate With Cleavage of Plasma “Readthrough” Acetylcholinesterase”, Journal of Molecular Neuroscience, 21: 199-212, 2003.
Cohen et al. “Neuronal Overexpression of ‘Readthrough’ Acetylcholinesterase Is Associated With Antisense-Suppressible Behavioral Impairments”, Molecular Psychiatry, 7: 874-885, 2002.
Conner et al. “Detection of Sickle Cell βS-Globin Allele by Hybridization With Synthetic Oligonucleotides”, Proc. Natl. Acad. Sci. USA, 80: 278-282, 1983.
Costa et al. “Functional Genomics of the Paraoxonase (PON1) Polymorphisms: Effect on Pesticide Sensitivity, Cardiovascular Disease, and Drug Metabolism”, Annual Reviews in Medicine, 54: 371-392, 2003.
Cotton et al. “Reactivity of Cytosine and Thymine in Single-Base-Pair Mismatches With Hydroxylamine and Osmium Tetroxide and Its Application to the Study of Mutations”, Proc. Natl. Acad. Sci. USA, 85: 4397-4401, 1988.
Curcio et al. “Multiplex High-Throughput Solid-Phase Minisequencing by Capillary Electrophoresis and Liquid Core Waveguide Fluorescence Detection”, Electrophoresis, 23: 1467-1472, 2002.
Curley et al. “Isoform—Specific Effects of Apoe on Anxiety in Probable Ad Patients and Apoe-/- Mice”, 2002: P. Abstract No. 883.2, 2002. Database BIOSIS 'Online! Bioscience Information Service, Database Acc. No. PREV200300379477 & Society for Neuroscience Abstract Viewer and Itinery Planner, vol. 2002: P.Abstract No. 883.2, 32nd Annual Meeting for the Society for Neuroscience, Orlando, Fa., USA, 2002.
Dantoine et al. “Implication des Facteurs Vasculaires dans les Troubles Cognitifs du Sujet Âgé: Relation Entre le Polymorphisme 192 de la Paraoxonase 1 et la Maladie d'Alzheimer”, Revue de Medicine Interne, P.606S, 2002. Abstract.
Davies et al. “The Effect of the Human Serum Paraoxonase Polymorphism Is Reversed With Diazoxon, Soman and Sarin”, Nature Genetics, 14: 334-336, 1996.
Day et al. “High-Throughput Genotyping Using Horizontal Polyacrylamide Gels With Well Arranged for Microplate Array Diagonal Gel Electrophoresis (MADGE)”, BioTechniques, 19(5): 830-835, 1995.
Deustch et al. “ARP—A Novel Hematopoietic Growth Factor and Stress Signal Derived From Acetylcholinesterase”, Blood, 94: 46A, 1999. Abstract.
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