Method for assessing sensitivity of tumor cells to cephalomannin

Details Method for assessing sensitivity of tumor cells to cephalomannin Method for assessing sensitivity of tumor cells to cephalomannin

1993-01-29

1997-11-18

Phelan, D. Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424400, 424449, 424450, 436 63, 436 64, 436815, 5147723, A61F 1300

Patent

active

056885172

ABSTRACT:
A method for assessing the sensitivity of a patient's tumor cells to cephalomannine and 10-deacetyltaxol in order to treat those tumor cells involves the removal of a sample of the tumor cells and establishing a cell line therefrom. Cells from the cell line are cultured and then contacted with varying concentrations of cephalomannine or 10-deacetyltaxol to form treated cells. The treated cells are assessed to determine the cytotoxic effect of the cephalomannine and/or the 10-deacetyltaxol and, where cytotoxic response is exhibited, a therapeutic dosage is formulated using the selected concentration of cephalomannine or 10-deacetyltaxol and a carrier material. The method is particularly useful for neural and glial tumor cells.

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