Method for assessing risk of diabetes-associated pathologic cond

Details Method for assessing risk of diabetes-associated pathologic cond Method for assessing risk of diabetes-associated pathologic cond

1990-08-17

1993-07-27

Housel, James C.

Chemistry: analytical and immunological testing

Biological cellular material tested

436 94, 436104, 436173, 436811, G01N 3348, G01N 2408

Patent

active

052310310

ABSTRACT:
Concentrations of one or more carbohydrates phosphorylated at a secondary hydroxyl, including fructose-3-phosphate and sorbitol-3-phosphate, in biological tissue or cells of diabetic patients are determined by .sup.31 P NMR Spectroscopy, High Performance Liquid Chromatography (HPLC) or other appropriate analytical techniques. Elevated levels of such phosphorylated carbohydrates, relative to a prescribed standard or threshold level, are associated with an increased risk for developing the degenerative complications of diabetes. A method is provided for determining the relative concentrations of such phosphorylated carbohydrates, whereby the relative risk of a patient for the development of diabetic complications and the efficacy of therapeutic intervention in prevention of such complications may be assessed.

REFERENCES:
patent: 4906468 (1990-03-01), Saltiel

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