Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-07-05
2011-07-05
Myers, Carla (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S024100, C536S024330
Reexamination Certificate
active
07972779
ABSTRACT:
The present invention relates to diagnostic methods for assessing predisposition of a subject to a mental disorder phenotype having an association with an at-risk allele of a brain-functional gene having a plurality of alleles, the association being conditioned by a pathogenic environmental risk factor status condition. Additionally, the invention relates to methods for discovering a conditional association between a mental disorder phenotype and an at-risk allele of a brain-functional gene having a plurality of alleles, the association being conditioned by a pathogenic environmental risk factor status condition.
REFERENCES:
patent: 2 344 093 (2002-08-01), None
Caspi et al. Science. Aug. 2002. 297: 851-854.
Gelernter et al. Human Genetics. 1997. 101: 243-246.
Wang et al. PLoS biology. 2007. 5: 0335-0342.
Surtees et al. Biological Psychiatry. 2006. 59: 224-229.
Gillespie et al. Psychological Medicine. 2005. 35: 101-111.
Lucentini. The Scientist. Dec. 2004, p. 20.
Chipman et al. American Journal of Medical Genetics. 2007. 144B: 561-565.
Chorbov et al. American Journal of Medical Genetics. 2007. 144B. 830-833.
Taylor et al Biol Psychiatry. 2006. 60: 671-676.
Risch et al. JAMA. Jun. 17, 2009. 301(23): 2462-2471.
Munafo et al. Biol Pyschiatry. 2009. 65 : 211-219.
Mental Health: A Report of the Surgeon General, Chapter 4 “Stressful Life Events,” available via url: <surgeongeneral.gov/library/mentalhealth/chapter4/sec1—1.html>, printed on Mar. 21, 2011.
Bennett, A.J., et al. “Early Experience and Serotonin Transporter Gene Variation Interact to Influence Primate CNS Function,” Molecular Psychiatry, vol. 7, No. 1, pp. 118-122 (2002).
Champoux, M., et al. “Serotonin Transporter GEne Polymorphism, Differential Early Rearing, and Behavior in Rhesus Monkey Neonates,” Molecular Psychiatry, vol. 7, No. 10, pp. 1058-1063 (2002).
Hu X., et al. “Genotyping of the HTTLPR Ins/Del by dHPLC followed by Association/Linkage Disequilibrium to Behavior in a Southwest American Indian Isolate,” American Journal of Human Genetics, vol. 7, No. 2, pp. 213-216 (2002).
Lesch, K.P., et al. “The 5-HT Transporter Gene-Linked Polymorphic Region (5-HTTLPR) in Evolutionary Perspective: Alternative Biallelic Variation in Rhesus Monkeys” Journal of Neural Transmission vol. 104 No. 11-12 pp. 1259-1266 (1997).
Lesch, K.P. “Molecular Foundation of Anxiety Disorders,” Journal of Neural Transmission, vol. 108, No. 6, pp. 717-746 (2001).
Moreno, F.A. “Association Between a Serotonin Transporter Promoter REgion Ploymorphism and Mood Response During Tryptophan Depletion,” Molecular Psychiatry, vol. 7, No. 2, pp. 213-216 (2002).
Rosenthal, N.E., et al. “Role of Serotonin Transporter Promoter Repeat Length Polymorphism (5-HTTLPR) in Seasonality and Seasonal Affective Disorder,” Molecular Psychiatry vol 3 No. 2 pp. 175-177 (1998).
Veenstra-Vanderweele, J., et al. “Pharmacogenetics and the Serotonin System: Initial Studies and Future Directions,” European Journal of Pharmacology, vol. 410, No. 2-3, pp. 165-181 (2000).
Cervilla J, et al., “The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish Predict-Gene cohort,” Mol. Psychiatry 12:748-755 (2007).
Covault J, et al., “Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use,” Biol. Psychiatry 61:609-616 (2007).
Dick D, et al., “Association analyses of the serotonin transporter gene with lifetime depression and alcohol dependence in the collaborative study on the genetics of alcoholism (COGA) sample,” Psychiatr. Genet. 17:35-38 (2007).
Eley T, et al., “Gene-environment interaction analysis of serotonin system markers with adolescent depression,” Mol. Psychiatry 9:908-915 (2004).
Fox N, et al., “Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood,” Psychol. Sci. 16:921-926 (2005).
Grabe H, et al., “Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden,” Mol. Psychiatry 10:220-224 (2005).
Gibb B, et al., “Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts among adult psychiatric inpatients,” Suicide Life Threat. Behav. 36:687-693 (2006).
Jacobs N, et al., “Stress-related negative affectivity and genetically altered serotonin transporter function,” Arch. Gen. Psychiatry 63:989-996 (2006).
Kaufman J, et al., “Brain-Derived Neurotrophic Factor—5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in children,” Biol. Psychiatry 59:673-680 (2006).
Kaufman J, et al., “Social supports and serotonin transporter gene moderate depression in maltreated children,” PNAS 101:17316-17321 (2004).
Kendler K, et al., “The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication,” Arch. Gen. Psychiatry 62:529-535 (2005).
Kim J, et al., “Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders,” Biol. Psychiatry 62:423-528 (2007).
Lenze E, et al., “Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture,” Am. J. Geriatr. Psychiatry 13:428-432 (2005).
Mandelli L, et al., “Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders,” Int. J. Neuropsychopharmacol. 10:437-447 (2007).
Nakatani D, et al., “Influence of serotonin transporter gene polymorphism on depressive symptoms and new cardiac events after acute myocardial infarction,” Am. Heart J. 150:652-658 (2005).
Roy A, et al., “Interaction between childhood trauma and serotonin transporter gene variation in suicide attempts,” Neuropsychopharmacology 32:2046-2052 (2007).
Scheid J, et al., “Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype,” Genes Brain Behav. 6:453-464 (2007).
Stein M, et al., “Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders,” Neuropsychopharmacology [epub ahead of print on Apr. 25, 2007].
Taylor S, et al., “Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology,” Biol. Psychiatry 60:671-676 (2006).
Wilhelm K, et al., “Life events, first depression onset and the serotonin transporter gene,” Br. J. Psychiatry, 188:210-215 (2006).
Zalsman G, et al., “Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression,” Am. J. Psychiatry, 163:1588-1593 (2006).
Andrews, G., Antstey, K., Brodaty, H. et al. (1999). Recall of depressive episodes, 25 years previously. Psychol Med 29: 787-791.
Andrews G., Poulton R., Skoog I. (2005). Lifetime risk for depression: Restricted to a minority or waiting for most? Brit J. Psychiatr 187: 495-496.
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., Gingrich, J. A. (2004). Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science, 306, 879-881.
Araya, Ricardo, Jon Heron, Mary-Anne Enoch, Jonathan Evans, Glyn Lewis, David Nutt, David Goldman, (2008). Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 9999(9999), n/a.
Barr, C. S., Newman, T. K., Shanno
Caspi Avshalom
Moffitt Terrie E.
Myers Carla
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
LandOfFree
Method for assessing predisposition to depression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for assessing predisposition to depression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for assessing predisposition to depression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2686783