Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1996-12-19
1999-09-21
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 71, 435 78, C12Q 100, G01N 3353
Patent
active
059552590
ABSTRACT:
The present invention relates to a method for assessing the ability of a compound to modulate the formation of a complex between a potassium channel and a protein tyrosine kinase. The method comprises the steps of (1) contacting a first polypeptide comprising the proline-rich binding region of the potassium channel, a second protein comprising the SH3 binding domain of the protein tyrosine kinase and the compound to be assessed; and (2) measuring the extent of complex formation between the first polypeptide and the second polypeptide.
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Holmes Todd C.
Levitan Irwin B.
Brandeis University
Feisee Lila
Ungar Susan
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