Method for assessing fetal lung maturity using amniotic fluid sa

Details Method for assessing fetal lung maturity using amniotic fluid sa Method for assessing fetal lung maturity using amniotic fluid sa

1993-10-25

1995-08-22

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Lipids, triglycerides, cholesterol, or lipoproteins

435 19, 435 71, 436 63, 436162, 436178, G01N 3392

Patent

active

054439892

ABSTRACT:
The present invention provides an accurate, rapid and precise methodology for assessing maturity of the lungs in a fetus prior to birth, especially for premature fetuses having a gestation period of 37 weeks or less. The methodology quantitatively measures a specific phosphoglyceride, dipalmitoyl phosphatidyl choline, in samples of amniotic fluid for the assessment of fetal lung maturity. The process enzymatically cleaves such phophoglycerides and preferably detects the resulting diacylglycerols by HPTLC-reflectance spectrodensitometry.

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