Method for assaying photosensitizing drug in whole blood

Details Method for assaying photosensitizing drug in whole blood Method for assaying photosensitizing drug in whole blood

1996-12-31

1998-12-08

Wallenhorst, Maureen M.

Chemistry: analytical and immunological testing

Optical result

356 39, 356317, 356318, 600310, 600322, 600476, 600477, G01N 2100

Patent

active

058468340

ABSTRACT:
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength, is determined by the steps of drawing a blood sample from the patient, diluting the blood sample to form a diluted sample, irridating the diluted sample with an interrogation light at an interrogation wavelength range at an absorption band bluer than the treatment light wavelength, measuring a magnitude of an emission signal at the treatment light wavelength, the emission signal caused by the irradiation of the diluted sample, and comparing the measured magnitude to a magnitude/concentration calibration curve to determine the concentration of the photosensitizing drug.

REFERENCES:
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Ronn et al. "Interspecies Pharmacokinetics . . . " Proceedings of SPIE, vol. 2625, pp. 118-123, 1996.
Ronn et al. "Meso-tetra(hydroxyphenyl)chlorin . . . " Proceedings of SPIE, vol. 2133, pp. 112-115, 1994.
Lofgren et al. "Efficacy of Intravenous . . . " British Journal of Cancer, vol. 72, pp. 857-864, 1995.

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