Method for assaying photosensitizing drug in tissue

Details Method for assaying photosensitizing drug in tissue Method for assaying photosensitizing drug in tissue

1996-12-31

2000-08-22

Wallenhorst, Maureen M.

Chemistry: analytical and immunological testing

Optical result

436179, 356317, 356318, 600310, 600476, 600477, G01N 2100

Patent

active

061071013

ABSTRACT:
A concentration of a photosensitizing drug in a patient, for PhotoDynamic Therapy treatment of the patient by a treatment light at a treatment light wavelength is determined by the steps of drawing a tissue sample from the patient, powderizing the tissue sample, extracting the photosensitizing drug from an amount of the powderized tissue sample with a solvent to form an extract, irradiating the extract with an interrogation light at an interrogation wavelength range of an absorption band bluer than the treatment light wavelength, measuring a magnitude of an emission signal at the treatment light wavelength, the emission signal caused by the irradiation of the extract, and comparing the measured magnitude to a magnitude/concentration calibration curve to determine the concentration of the photosensitizing drug.

REFERENCES:
patent: 5015463 (1991-05-01), Dougherty et al.
patent: 5205291 (1993-04-01), Potter
patent: 5589932 (1996-12-01), Garcia-Rubio et al.
Ronn et al. "Interspecies Pharmacokinetics . . . " Proceedings of SPIE, vol. 2625, pp. 118-123, 1996.
Ronn et al. "Meso-tetra(hydroxyphenyl)chlorin . . . " Proceedings of SPIE, vol. 2133, pp. 112-115, 1994.
Lofgren et al. "Efficacy of Intravenous . . . " British Journal of Cancer, vol. 72, pp. 857-864, 1995.

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