Method for assaying endotoxin in a whole blood sample or protein

Details Method for assaying endotoxin in a whole blood sample or protein Method for assaying endotoxin in a whole blood sample or protein

1991-11-08

1994-02-15

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

435 4, 435 23, 435 24, 436175, C12Q 134, C12Q 100, C12Q 137, G01N 100

Patent

active

052866254

ABSTRACT:
A method of assaying an endotoxin using the limulus amebocyte lysate component which comprises pretreating whole blood with nitric acid and a surfactant selected from among polyoxyethylene ethers represented by the following formula: ##STR1## wherein n is an integer of from 8 to 40; or: ##STR2## polyoxyethylene sorbitans, n-alkylglucopyranosides, sodium dodecylsulfate and lithium dodecylsulfate, which enables an efficient and accuate assay of an endotoxin.

REFERENCES:
patent: 4406832 (1983-09-01), Mills
patent: 4495294 (1985-01-01), Nakahara
patent: 4510241 (1985-04-01), Mills
H. Tamura et al., "A New Sensitive Method for Determining Endotoxin in Whole Blood", Clinica Chimica Acta, 200:35-42 (1991).

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