Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-03-15
2005-03-15
Pak, Michael (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007800, C435S007600
Reexamination Certificate
active
06867008
ABSTRACT:
The invention provides a method for assaying compounds that affect cell division by determining the interaction between estrogen receptor ERβ and MAD2, a cell cycle checkpoint protein.
REFERENCES:
Mendelsohn et al., “Mechanisms of Estrogen Action in the Cardiovascular System,” Nobel Symposium (Jun. 30, 1999).
Iafrati et al., “Estrogen Inhibits the Vascular Injury Response in Estrogen Receptor α-deficient Mice”,Nature Medicine, vol. 3, No. 5, pps. 545-548, 1997.
Lindner et al., “Increased Expression of Estrogen Receptor-β mRNA in Male Blood Vessels After Vascular Injury”,Circulation. Research., 83: 224-229, 1998.
Elledge, “Mitotic Arrest: Mad2 Prevents Sleepy from Waking Up the APC”,Science, vol. 279, pps. 999-1000, 1998.
Clark Paul T.
Clark & Elbing LLP
New England Medical Center Hospitals Inc.
Pak Michael
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