Chemistry: analytical and immunological testing – Clotting or clotting factor level tests
Reexamination Certificate
2011-04-12
2011-04-12
Alexander, Lyle A (Department: 1773)
Chemistry: analytical and immunological testing
Clotting or clotting factor level tests
C422S073000, C422S076000
Reexamination Certificate
active
07923256
ABSTRACT:
This invention is a disposable cartridge for use at the patient side to perform traditional coagulation assays on fresh whole blood or blood derivative samples. The cartridge, in use with an electronic analyzer allows a fluid sample to be metered and quantitatively mixed with reagents which activate the coagulation cascade. An artificial substrate for thrombin, the enzyme whose action results in clot formation is also provided. Clot formation is subsequently detected using a microfabricated sensor also housed within the cartridge which detects electrochemically the product of the thrombin reaction upon the synthetic substrate.
REFERENCES:
patent: 4002269 (1977-01-01), Negersmith
patent: 4304853 (1981-12-01), Jozefonvicz et al.
patent: 4497744 (1985-02-01), Fawzi
patent: 4749552 (1988-06-01), Sakisako et al.
patent: 4756884 (1988-07-01), Hillman et al.
patent: 4806312 (1989-02-01), Greenquist
patent: 4929426 (1990-05-01), Bodai et al.
patent: 5096669 (1992-03-01), Lauks et al.
patent: 5104813 (1992-04-01), Besemer et al.
patent: 5124661 (1992-06-01), Zelin et al.
patent: 5200051 (1993-04-01), Cozzette et al.
patent: 5208163 (1993-05-01), Charlton et al.
patent: 5229172 (1993-07-01), Cahalan et al.
patent: 5302348 (1994-04-01), Cusack et al.
patent: 5447440 (1995-09-01), Davis et al.
patent: 5534226 (1996-07-01), Gavin et al.
patent: 5580794 (1996-12-01), Allen
patent: 5628961 (1997-05-01), Davis et al.
patent: 5677133 (1997-10-01), Oberhardt
patent: 5798215 (1998-08-01), Cathey et al.
patent: 5916522 (1999-06-01), Boyd et al.
patent: 5919711 (1999-07-01), Boyd et al.
patent: 6060323 (2000-05-01), Jina
patent: 6130098 (2000-10-01), Handique et al.
patent: 6143247 (2000-11-01), Sheppard et al.
patent: 6438498 (2002-08-01), Opalsky et al.
patent: 6750053 (2004-06-01), Opalsky et al.
patent: 7736901 (2010-06-01), Opalsky et al.
patent: 2010/0240067 (2010-09-01), Opalsky et al.
patent: WO0159425 (2001-08-01), None
Becker, et al., “Prothrombin time test with chromogenic peptide substrate as thrombin indicator”, Haemostasis, (1982) 12: 73.
Keeth, et al., A clinical evaluation of the HemoTec ACT, Proc. Am. Acad. Cardiovascular Perfusion, (1988) 9: 22-25.
International Search report for PCT/US00/31158 dated Feb. 1, 2001, 2 pages.
Cheadle Rhonda J.
Lauks Imants R.
Maczuszenko Andrzej
Opalsky Cindra A. Widrig
Opalsky David
Abbott Point of Care Inc.
Alexander Lyle A
Katten Muchin & Rosenman LLP
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