Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1981-05-04
1983-09-20
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
A61K 3700
Patent
active
044056060
ABSTRACT:
A method for arresting fulminating infections of traumatized animal tissue comprises administering to the locus of the tissue trauma an agent capable of binding iron made available to infection-promoting organisms by body fluid released by the trauma. The agent is administered in an amount sufficient to bind all of the available iron, to thereby block the adsorption of the iron by the infection-promoting organisms. The agent preferably comprises one or more binding proteins having known specificity for iron-containing fractions of the body fluid. In particular, the protein haptoglobin may be utilized in the agent to complex with the hemoglobin fraction of blood, to deny access to the iron content by bacterial enzymes. The present method is preferably used in conjunction with existing infection-controlling therapy.
REFERENCES:
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Jones, R. L. et al. "A Low Molecular Weight Iron Binding Factor from Mammalian Tissue Which Potentiates Bacterial Growth In Vitro and In Vivo" J. of Exp. Med. 151:148-428, 1980.
Pagano, M. et al. "Kinetic Study of the Interaction Between Rat Haptoglobin and Rat Liver Cathepsin B", Can. J. Biochem. 58:410-417, (1980).
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Bobis Daniel H.
Evreka Inc.
Jackson David A.
Phillips Delbert R.
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