Method for applying a drug coating to a medical device

Details Method for applying a drug coating to a medical device Method for applying a drug coating to a medical device

2007-10-16

2007-10-16

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S425000, C424S426000, C607S115000, C607S116000, C607S120000

Reexamination Certificate

active

10260659

ABSTRACT:
A method for coating a medical device with a drug is provided. Energy, preferably thermal energy, is applied to a crystalline deposit of a drug on the surface of a medical device to increase the molecular mobility and form a conformable drug coating with a low density of micro-cracks and other mechanical defects that can degrade the coating toughness and effective adhesion to the device surface. In a preferred embodiment, solution evaporation methods are used to deposit a crystalline coating of an anti-inflammatory steroid on a medical electrode. Heat applied at a controlled temperature, for a predetermined amount of time, induces a solid-state phase change of the drug coating providing a smooth, uniform, well-attached, conformable coating to form a layer that will elute from the electrode over time when implanted in a patient's body.

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