Method for anti-cholinergic blockage of withdrawal symptoms in s

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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514223, 514304, 514557, A61K 3124, A61K 3144, A61K 3154

Patent

active

045553971

ABSTRACT:
Subcutaneously injecting a patient with a solution of atropine and scopolamine, potentiated by chlorpromazine alleviates withdrawal symptoms attributed to the cessation of chronic nicotine blockage. Auricular injections give immediate effects and minimize peripheral anti-cholinergic activity. The treatment is administered during an initial office visit.

REFERENCES:
patent: 3764680 (1973-10-01), Phillips
Physician's Desk Reference, pp. 1915-1918 (1983).
Goodman and Gilman's The Pharmacological Basis of Therapeutics, 6th Ed., pp. 394-414.
Brimblecombe, R. W., Drug Actions on Cholinergic Systems, University Park Press (1974), pp. 93-97.
Ketchum, J. S. et al., Atropine, Scopolamine and Ditran: Comparative Pharmacology and Antagonists in Man, Psychopharmacologia, 28, pp. 121-145 (1974).
Gordon, "Psychopharmacological Agents", vol. II, Academic Press, New York, 1967, pp. 38-39.
Ebenezer, "Atropine Pretreatment Reverses the Initial Depressant Effect of Nicotine on the Spontaneous Activity of Naive Rats", C.A., v. 99, 100796b.
Ebenezer, "Atropine Pretreatment Interferes with the Development of Tolerance to the Depressant Effect of Nicotine", C.A., v. 99, 100797c.
Jaffe, "Tobacco Use and Tobacco Use Disorder", Psychopharmacology: A Generation of Progress, pp. 1665-1676, Raven Press, (1978).

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