Chemistry: analytical and immunological testing – Immunochemical pregnancy determination
Patent
1996-01-11
1998-11-10
Housel, James C.
Chemistry: analytical and immunological testing
Immunochemical pregnancy determination
435 6, 435 71, 435806, 436 65, 436 86, 436 87, 436814, 436906, G01N 3353, G01N 3374, G01N 3376
Patent
active
058343172
ABSTRACT:
A method for antenatal screening for chromosomal and other abnormalities in an unborn child is determined by measuring the gestational age discrepancy of the pregnant mother. This data is determined (a) by reference to the last menstrual period, and (b) a biometric measurement of the fetus. The difference between the ages as determined using (a) and (b) is calculated. This calculated difference is then examined using reference data to determine fetal abnormalities. These data can also be used with assay of maternal fluids for various pregnancy markers.
REFERENCES:
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Reynolds et al., 1990. The mathematical basis of multivariate risk screening with special reference to screening for Down's syndrome associated pregnancy. Annals of Clinical Biochemistry 27 (Part 5):452-458.
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Crossley et al., 1991. Prenatal screening for chromosome abnormalities using maternal serum chorionic gonadotrophin, alpha-fetoprotein, and age. Prenatal Diagnosis 11:83-101.
Grun James L.
Housel James C.
Johnson & Johnson Clinical Diagnostics Inc.
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