Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Reexamination Certificate
2005-12-20
2005-12-20
Spivack, Phyllis G. (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
C514S731000
Reexamination Certificate
active
06977272
ABSTRACT:
A method of antagonizing inhibition effects of alcohol on cell adhesion is disclosed comprising contacting a cell-adhesion molecule expressing cell with an effective amount of a compound, wherein the compound comprises an alcohol selected from the group consisting of 3-pentanol, 2-pentanol, cyclopentanol, 4-methyl-1-pentanol, 2-methyl-2-pentanol, and 2,6-diisopropylphenol.
REFERENCES:
patent: 5496851 (1996-03-01), Grinnell
patent: 6169071 (2001-01-01), Blaschuk et al.
patent: 6169072 (2001-01-01), Jonczyk et al.
patent: 6359015 (2002-03-01), Charness et al.
Fransen E, Lemmon V, Van Camp G. Vits L, Coucke P and Willems PJ (1995) CRASH Syndrome: Clinical Spectrum of Corpus Callosum Hypoplasia, Retardation, Adducted Thumbs, Spastic Paraparesis and Hydrocephalus Due to Mutations in One Single Gene, L1. [Review]Eur. J. Hum. Genet.3:273-284.
Uyemura K, Asou H, Yazaki T and Takeda Y (1996) Cell-adhesion proteins of the immunoglobulin superfamily in the nervouse system.Essays in Biochemistry.31:37-48.
Anders DL, Blevins T, Sutton G, Swope S, Chandler LJ and Woodward JJ (1999) Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed in HEK 293 cells.J. Neurochem.72:1389-1393.
Bearer CF, Swick, AR, O'Riordan MA and Cheng G (1999) Ethanol inhibits L1-mediated neurite outgrowth in postnatal rat cerebellar granule cells.J. Biol. Chem.274:13264-13270.
Beckstead MJ, Phelan R and Mihic SJ (2001) Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function.J. Biol. Chem.276:24959-24964.
Charness ME, Querimit LA and Diamond I (1986)J. Biol. Chem.261:3164-3169.
Charness ME, Safran RM and Perides G (1994) Ethanol inhibits neural cell-cell adhesion.J. Biol. Chem.269:9304-9309.
Charness ME, Simon RP and Greenberg DA (1989) Ethanol and the nervous system.N. Engl. J. Med.321:442-454.
Chen S-Y, Wilkemeyer MF, Sulik KK and Charness ME (2001) Octanol antagonism of ethanol teratogenesis.Faseb J.15(9):1649-1651.
Coe IR, Dohrman DP, Constantinescu A, Diamond I and Gordon AS (1996) Activation of cyclic AMP-dependent protein kinase reverses tolerance of a nucleoside transporter to ethanol.J. Pharmacol. Exp. Ther.276:365-369.
Crossin KL and Krushel LA (2000) Cellular signalling by neural cell adhesion molecules of the immunoglobulin superfamily.Developmental Dynamics218:260-279.
Demyanenko GP, Tsai AY and Maness PF (1999) Abnormalities in neuronal process extension, hippocampal development, and the ventriclar system of L1 knockout mice.J. Neurosci.19:4907-4920.
Diamond I and Gordon AS (1997) Cellular and molecular neuroscience of alcoholism.Physiol. Rev77:1-20.
Dwyer DS and Bradley RJ (2000) Chemical properties of alcohols and their protein binding sites.Cell Mol. Life Sci.57:265-275.
Franks NP & Lieb WR (1984) Do general anaesthetics act by competitive binding to specific receptors?Nature310:599-601.
Franks NP and Lieb WR (1994) Molecular and cellular mechanisms of general anaesthesia.Nature367:607-614.
Fransen E, Dhooge R, Vancamp G, Verhoye M, Sijbers J, Reyniers E, Soriano P, Kamiguchi H, Willemsen R, Koekkoek SKE, Dezeeuw CI, Dedeyn PP, Vanderlinden A, Lemmon V, Kooy RF and Willems PJ (1998) L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns.Human Mol. Genet.7:999-1009.
Goldstein DB (1983)Pharmacology of Alcohol.Oxford, New York.
Harris RA (1999)Ethanol actions on multiple ion channels: which are important? Alcohol Clin. Exp. Res.23:1563-1570.
Harris T, Shahidullah M, Ellingson JS and Covarrubias M (2000) General anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channel.J. Biol. Chem.275:4928-4936.
Hodge CW, Mehmert KK, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM and Messing RO (1999) Supersensitivity to allosteric GABA(A) receptor modulators and alcohol in mice lacking PKCepsilon.Nature Neuroscience2:997-1002.
Hundle B, McMahon T, Dadgar J. Chen CH, Mochly-Rosen D and Messing RO (1997) An inhibitory fragment derived from protein kinase Cepsilon prevents enhancement of nerve growth factor responses by ethanol and phorbol esters.J. Biol. Chem.272:15028-15035.
Kamiguchi H and Lemmon V (1998) A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone.J. Neurosci.18:3749-3756.
Lewohl JM, Wilson WR, Mayfield RD, Brozowski SJ, Morrisett RA and Harris RA (1999) G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action.Nat. Neurosci.2:1084-1090.
Lovinger DM (1999) 5-HT3 receptors and the neural actions of alcohols: an increasingly exciting topic.Neurochem. Int.35:125-130.
Lüthl A, Laurent J-P, Figurov A, Muller D and Schachner M (1994) Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM.Nature372:777-779.
Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR and Harris RA (1996) A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.Mol. Pharmacol.50:402-406.
Msacia MP, Trudell JR and Harris RA (2000) Specific binding sites for alcohols and anesthetics on ligand-gated ion channels.Proc. Natl. Acad. Sci. U.S.A.97:9305-9310.
Mascia MP, Wick MJ, Martinez LD and Harris RA (1998) Enhancement of glycine receptor function by ethanol: role of phosphorylation.Br. J. Pharmacol.125:263-270.
McCreery MJ and Hunt WA (1978) Physico-chemical correlates of alcohol intoxication.Neuropharmacol.17:451-461.
McKenzie D, Franks NP and Lieb WR (1995) Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones ofLymnaea stagnalis. Br. J. Pharmacol.115:275-282.
Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA and Harrison NL (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors [see comments].Nature389:385-389.
Minami K, Gereau RWt, Minami M. Heinemann SF and Harris RA (1998). Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed inXenopus laevisoocytes.Mol. Pharmacol.53:148-156.
Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K and Niki H (1997) Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function [see comments].Science278:698-701.
Peoples RW, Li C and Weight FF (1996) Lipids vs protein theories of alcohol action in the nervous system.Ann. Rev. Pharmacol. Toxicol.36: 185-201.
Perides G, Hu G, Rueger DC and Charness ME (1993) Osteogenic Protein-1 Regulates L1 and Neural Cell Adhesion Molecule Gene Expression in Neural Cells.J. Biol. Chem.268:25197-25205.
Perides G, Safan RM, Downing LA and Charness ME (1991) Regulation of Neural Cell Adhesion Molecule and L1 by the Transforming Growth Factor-β Superfamily.J. Biol. Chem.269:765-770.
Perides G, Safran RM, Rueger DC and Charness ME (1992) induction of the neural cell adhesion molecule and neuronal aggregation by osteogenic protein 1.Proc. Natl. Acad. Sci.(USA) 89:10326-10330.
Ramanathan R, Wilkemeyer MF, Mittal B, Perides G and Charness ME (1996) Ethanol inhibits cell-cell adhesion mediated by human L1.J. Cell Biol.133:381-390.
Rose SP (1995) Glycoproteins and memory formation.Behav. Brain Res.66:73-78.
Sanna E, Dildy-Mayfield JE and Harris RA (1994) Ethanol inhibits the function of 5-hydroxytryptamine type 1c and muscarinic M1 G protein-linked receptors inXenopus oocytesexpressing brain mRNA: role of protein kinase C.Mol. Pharmacol.45:1004-1012.
Slater SJ, Cox KJ, Lombardi JV, Ho C, Kelly MB, Rubin E and Stubbs CD (1993) Inhibition of protein kinase C by alcohols and anaesthetics.Nature364:82-84.
Solem M, McMahon T and Messing RO (1997) Protein kinase A regulates regulates inhibition of N- and P/Q-type calcium channels by ethanol in PC12 cells,J. Pharmacol. Exp. Ther.282:1487-1495.
Uyemura K, Asou H, Yazaki T and Takeda Y (1996)Essays Biochem.31:37-48.
Vallejo Y, Hortsch M and Dubreuil RR (1997) Ethanol Does Not Inhibit the Adhesive Activity ofDrosophila Neuro
Charness Michael E.
Wilkemeyer Michael F.
Dinesh Agarwal, P.C.
President and Fellows of Harvard College
Spivack Phyllis G.
The United States of America as represented by the United States
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