Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Patent
1996-09-10
1998-11-17
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
424 91, A61K 4900
Patent
active
058372202
ABSTRACT:
A method for analyzing the immunosuppressant activity of Kv1.3 inhibitors using the mini- and micro-pig. These pig models have been found to have K.sub.v 1.3 channels very similar to man both in function and setting of membrane potential of T-lymphocytes, and respond similarly in a mixed lymphocyte reaction (MLR) to the K.sub.v 1.3 channel blockers. The mini-pig and micro-pig provide useful in vivo animal models for studying the immunosuppressant activity of Kv1.3 channel blockers that would be expected to function in man.
REFERENCES:
patent: 5071964 (1991-12-01), Dustin et al.
patent: 5397702 (1995-03-01), Cahalan et al.
Mix, et al., "Effect on Ion Channel Blockers on Immune Response and Course of Experimental Allergic Neuritis", Allergic Neutritis, Brain, vol. 112, pp. 1405-1418, 1989.
Kaczorowski, et al., "Lymphocyte Ion Channels as a Target for Immunosuppression", Perspectives in Drug Discovery, vol. 2(1), pp. 233-248, 1994.
Koo, et al., Biol. Abstract, vol. 048, Issue 007, 1996.
Lewis, et al., "Potassium and Calcium Channels in Lymphocytes", Ann. Rev. of Immunol., vol. 13, pp. 623-653, 1995.
Lin et al, Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J. of Exp. Med., vol. 177, No. 3, pp. 637-645, Mar. 1, 1993.
Mallard, B.A., et al., "Genetics and Other Effects on Antibody and Cell Mediated Immune Response in Swine Leucocyte Antigen (SLA) Defined Miniature Pigs", An. Genetics, vol. 20, pp. 167-178, 1989.
Taura, Y., et al., "Fetal Pancreas Translation in Miniature Swine IV. Suppression of DTH and MLR Responses by Treatment with Ultraviolet Light Irradiated Peripheral Blood Lymphocytes", Transplantation, vol. 50(1), pp. 136-140, 1990.
Blake J. Thomas
Feeney William P.
Koo Gloria C.
Talento Althea D.
Camara Valerie J.
Chambers Jasemine C.
Clark Deborah J. R.
Daniel Mark R.
Garcia-Rivas J. Antonio
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