Method for analyzing substance

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic

Reexamination Certificate

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C436S527000

Reexamination Certificate

active

10469932

ABSTRACT:
A method for analyzing a substance, comprising: a step of obtaining a dispersion complex by co-existing fine particles having a dispersion property higher than that of lyophobic fine particles in a dispersion phase of the lyophobic fine particles at a concentration sufficient for covering a periphery of a lyophobic fine particle group; a step of contacting the dispersion complex and a fluid containing an analyte; and a step of analyzing the analyte using an optical measuring means, wherein the lyophobic fine particles exist in the dispersion phase in a group for providing the surface enhancing effect. The method is effective for analysis of a slight amount substance or a low concentration substance.

REFERENCES:
patent: 9-70527 (1997-03-01), None
patent: 11-61209 (1999-05-01), None
Chang, R. et al., “Surface Enhanced Raman Scattering,” Plenum Press, New York and London, pp. 109, 126-127 (1982).
Kneipp, K. et al., “Surface-enhanced Raman scattering: A new tool for biomedical spectroscopy,” Current Science, vol. 77, No. 7, pp. 915-924 (1999).
Kneipp, K. et al., “Extremely Large Enhancement Factors in Surface-Enhanced Raman Scattering for Molecules in Colloidal Gold Clusters,” Soc. for Applied Spectroscopy, vol. 52, No. 12, pp. 1493-1497 (1998).
Hayat, M.A., “Colloidal Gold—Principles, Methods, and Applications [Methods for Synthesis of Colloidal Gold by Dean A. Handley],” Academic Press, Inc., San Diego, California, pp. 13-32 (1989).
Khlebtsov, N. et al., “Spectral Extinction of Colloidal Gold and Its Biospecific Conjugates,” Journal of Colloid and Interface Science, vol. 180, Article 0323, pp. 436-445 (1996).
Akbarian, F. et al., “Porous Sol-Gel Silicates Containing Gold Particles as Matrices for Surface-Enhanced Raman Spectroscopy,” Journal of Raman Spectroscopy, vol. 27, pp. 775-783 (1996).
Keitaro Nakamura et al.,“The Preparation of the Gold and Clay Coexisting Gel and its Properties of Surface-enhanced Raman Scattering,” (English translation of “Kin . Nendo Kyouzon Gel tai No Chousei to Hyomen Zoukyou Raman Sanran Tokusei”), The autumnal workshop proceedings 2000 of the Society of Power Technology, Japan, pp. 44-46 (2000).
Keitaro Nakamura et al., “Preparation of Gold-Clay Coexisting Gel and its Properties of Surface-enhanced Raman Scattering,” The autumnal workshop proceedings 1999 of the Society of Powder Technology, Japan, 44 (1999).

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