Method for analyzing protein or peptide

Details Method for analyzing protein or peptide Method for analyzing protein or peptide

2006-09-26

2006-09-26

Cole, Monique T. (Department: 1743)

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Reexamination Certificate

active

07112446

ABSTRACT:
In a method for efficiently analyzing a posttranslational modification of a protein using no enzyme, a protein or peptide to be analyzed is reacted with an acid (a thioester or hydrazine) under certain conditions. This makes it possible to detect variously modified states of a protein or peptide, whereby the identification of each specific modifying group and the position of each modified amino acid can be efficiently analyzed using a chemical method and a mass spectrometric apparatus.

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patent: 5962642 (1999-10-01), Tsugita et al.
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“Experimental Medicine”, Proteome Analytical Methods (published by Yodosha 2000), Chapter 2-II-4b and Chapter 2-IV, pp. 85-91 and 111-122.
A. Tsugita et al., “Application of chemical selective cleavage methods to analyze post-translational modification in proteins”,Proteomics 2001, vol. 1, pp. 1082-1091.

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