Method for analyzing intact capsules and tablets by near-infrare

Details Method for analyzing intact capsules and tablets by near-infrare Method for analyzing intact capsules and tablets by near-infrare

1988-03-10

1990-01-09

Lall, Parshotam S.

Boots, shoes, and leggings

364498, G06F 1520, G06F 1542

Patent

active

048932531

ABSTRACT:
The BEAST method, when used in conjunction with NIRS data at as few as one or two wavelengths, is able to quickly detect a wide variety of adulterants in capsules, obviating the need to open them for analysis. The ability of this technique to detect the absence of components that should be present as well as the presence of components that should be absent enables it even to signal the presence of adulterants that have no near-infrared absorption. The technique generally comprises the steps of obtaining spectra for a training set of unadulterated samples, representing each specturm as a point in a hyperspace, creating a number of training set replicates and a bootstrap replicate distribution, calculating the center of the bootstrap replicate distribution, obtaining a spectrum for an adulterated sample, transforming this spectrum into a point in hyperspace, and identifying the adulterated sample as abnormal based on a relationship between the adulterated sample's hyperspatial point and the bootstrap replicate distribution.

REFERENCES:
patent: 4286327 (1981-08-01), Rosenthal et al.
patent: 4399361 (1983-08-01), Zanzucchi et al.
patent: 4466076 (1984-08-01), Rosenthal
patent: 4496839 (1985-01-01), Bernstein et al.
patent: 4540282 (1985-09-01), Landa et al.
patent: 4633087 (1986-12-01), Rosenthal et al.
patent: 4640614 (1987-02-01), Roberts et al.
patent: 4652756 (1987-03-01), Ryan et al.
patent: 4692620 (1987-09-01), Rosenthal
patent: 4742228 (1988-05-01), Bischoff
patent: 4785184 (1988-11-01), Bien et al.
Wetzel, D. L., "Near-Infrared Reflectance Analysis, Sleeper Among Spectroscopic Techniques", Anal. Chem., 55(12): 1165-1172 (1983).
Hadzija, B. W., et al., "Simple Techniques to Detect and Identify Phentermine Adulteration," Forensic Sci. Int'l., 23:143-147 (1983).
Efron, B., "Nonparametric estimates of standard error: The jackknife, the bootstrap . . .", Biometrika, 68(3)589-599 (1981).
Mark, H. L., et al., "Qualitative Near-Infrared Reflectance Analysis Using Mahalanobis Distances,"Anal. Chem., 57:1449-1456 (1985).
Mark, H., "Normalized Distances for Qualitative Near-Infrared Reflectance Analysis," Anal. Chem., 58:379-384 (1986).
Honigs, D. E., et al., "Number of Samples and Wavelengths Required for the Training Set . . .", Appl. Spectr. 38(6):844-847 (1984).
Honigs, D. E., et al., "Near-Infrared Spectrophotometric Methods Development with a Limited Number of Samples . . .", Appl. Spectr. 39(6): 1062-1065 (1985).
Lodder, R. A., "Quantile BEAST Attacks the False-Sample Problem in Near-Infrared Reflectance Analysis" Unpublished Manuscript 1987.

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