Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2008-07-25
2011-11-29
Tsai, Carol S (Department: 2857)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C702S020000, C435S005000, C435S006120, C600S300000, C703S011000
Reexamination Certificate
active
08068994
ABSTRACT:
Significance of biological pathway in disease state is predicted by (a) providing expression level data for a plurality of biomolecules differentially expressed in a disease state, compared with same biomolecules expressed in a non-diseased state: (b) determining presence probability of the biomolecules in disease state; (c) determining effect of each biomolecule from the plurality of biomolecules on the expression of different downstream biomolecules within pathway to provide perturbation factor for each biomolecule in the pathway; (d) combining statistical significance of differentially expressed biomolecules present in the disease state, with a sum of perturbation factors for all of the biomolecules, generating an impact factor; (e) calculating statistical significance of impact factor based upon determined probability of having statistical significant presence of differentially expressed biomolecules in step (b) and the sum of perturbation factors in step (c); and (f) outputting statistical significance of impact factor for the pathway relevant to the disease.
REFERENCES:
patent: 2005/0154535 (2005-07-01), Sun et al.
patent: 2005/0165594 (2005-07-01), Chandra et al.
patent: 2007/0059685 (2007-03-01), Kohne
patent: 2008/0254447 (2008-10-01), Foekens et al.
patent: 2008/0307537 (2008-12-01), Bachoo
patent: 2009/0313189 (2009-12-01), Sun et al.
patent: 2010/0057368 (2010-03-01), Afeyan et al.
patent: 2010/0086935 (2010-04-01), Bevilacqua et al.
Harness & Dickey & Pierce P.L.C.
Tsai Carol S
Wayne State University
LandOfFree
Method for analyzing biological networks does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for analyzing biological networks, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for analyzing biological networks will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4261983