Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-n
Reexamination Certificate
2006-12-12
2006-12-12
Wallenhorst, Maureen M. (Department: 1743)
Chemistry: analytical and immunological testing
Heterocyclic carbon compound
Hetero-n
C436S056000, C436S086000, C436S089000, C436S091000, C436S173000, C530S409000, C546S102000, C546S159000, C546S278400, C548S364100, C548S542000
Reexamination Certificate
active
07148069
ABSTRACT:
The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.
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T. Hirai, et al.,“Development of a New Fluorescence Labeling Reagent Succinimido-2-Fluorenylcarbamate for Highly Sensitive Detection of N-Solanesyl-N, N′-BIS (3,4-Dimethoxybenzyl)Ethanediamine by HPLC”, Bunseki Kagaku, vol. 40, No. 5, May 5, 1991, pp. 233-238 (w/attached English Abstract).
Hirayama Kazuo
Miyano Hiroshi
Nakazawa Masakazu
Shimbo Kazutaka
Yahashi Akihisa
Ajinomoto Co. Inc.
Wallenhorst Maureen M.
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