Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2001-12-19
2008-12-02
Lu, Frank W (Department: 1634)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S006120, C435S007100, C204S157150, C536S023100, C530S350000
Reexamination Certificate
active
07459304
ABSTRACT:
The invention relates to a method for the analysis of macromolecules using a microarray on which a plurality of first at least partly different macromolecules are located in a known arrangement, wherein the microarray is arranged on a solid surface on which a region is defined whose wetting properties differ from the surrounding solid surface such that a liquid with a plurality of second macromolecules preferably stays thereon, the liquid with the second macromolecules is brought onto the solid surface and at least partly removed and the second macromolecules remaining after the removal process are detected in order to determine from the position which of the first macromolecules have formed a bond with second macromolecules. The invention further relates to a method wherein a surface wave is launched to the liquid to distribute and/or thoroughly mix the liquid on the microarray.
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Attached definition for “surface wave” (printed on Jul. 21, 2008).
Wang, Joseph, “From DNA Biosensors to Gene Chips,” Nucleic Acids Research 2000, vol. 28, Nr. 16, 15, Aug. 2000, pp. 3011-3016.
Advalytix AG
Dilworth & Barrese LLP
Lu Frank W
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