Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1996-06-10
1999-03-02
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436510, 436814, 436 65, 436 88, 436170, 422 56, 422 60, G01N 3353
Patent
active
058769447
ABSTRACT:
Disclosed is an improvement to a sandwich type immunoassay in which there is immobilized to a solid support an antibody which is specific to an epitope of the analyte whose presence or concentration is being sought and a first labeled antibody which is specific to another epitope of the analyte. The improvement involves providing a second labeled antibody which is specific to the first labeled antibody to thereby form a chain of two or more labeled antibodies which results in amplification of the signal generated upon formation of the sandwich.
REFERENCES:
patent: 4474892 (1984-10-01), Murad et al.
patent: 4703017 (1987-10-01), Campbell et al.
patent: 5326707 (1994-07-01), Franke et al.
Weir et al (Editors) "Handbook of Experimental Immunology, vol. 1: Immunochemistry" Blackwell Scientific Publications, USA pp. 35.24-35.25, 1986.
Bakalyar Heather A.
Bayer Corporation
Hutzell Paula K.
Jeffers Jerome L.
LandOfFree
Method for amplification of the response signal in a sandwich im does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for amplification of the response signal in a sandwich im, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for amplification of the response signal in a sandwich im will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-421399