Method for alleviating ischemic-reperfusion injury

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514730, 514738, A61K 31048

Patent

active

049391461

ABSTRACT:
A method for alleviating ischemic-reperfusion injury in a mammal which has suffered from a disease condition resulting from a deprivation of oxygen comprising the step of administering to the mammal alone, or in combination, an effective amount of an aliphatic alcohol having from 2 to 6 carbon atoms, a phenylalcohol having from 7 to 12 carbon atoms wherein the alcohol portion of the phenylalcohol has 1 or 2 carbon atoms, sorbitol and/or a polyol phosphate having from 3 to 9 carbon atoms or a salt thereof prior to or during the restoration of oxygen to alleviate ischemic-reperfusion injury.

REFERENCES:
patent: 3749783 (1973-07-01), Berger et al.
patent: 3788468 (1974-01-01), Gainer
patent: 3853993 (1974-12-01), Gainer
patent: 3953595 (1976-04-01), Holland
patent: 3975519 (1976-08-01), Gainer
Lucchesi et al., "Leukocytes and Ischemia-induced Myocardial Injury", Ann. Rev. Pharmacol. Toxicol. 26:201-224, 1986.
Hofmann et al., "The influence of reperfusion on infarct size after experimental coronary artery occlusion", Basic Res. Cardiol, 75:572-582, 1980.
Arfors et al., PCT Application No. WO 86/00812 dated Feb. 13, 1986.
J. C. Livesey et al., Radiation-Protective Drugs and Their Reaction Mechanisms, Noyes Publications, Park Ridge, N.J., 1985, pp. 62-64.
W. A. Cramp, Radiation Protection of Shigella Flexneri Y6R by Ethanol, B-mercaptoethanol and Several Polyhydric Alcohols, Int. J. Radiat. Biol. 15:227-232, 1969.
T. Sanner and A. Pihl, Significance and Mechanism of the Indirect Effect in Bacterial Cells, The Relative Protective Effect of Added Compounds in Escherichia coli B, Irradiated in Liquid and in Frozen Suspensions, Radiation Research 37:216-227, 1969.
S. R. Jolly et al., "Canine Myocardial Reperfusion Injury Its Reduction by the Combined Administration of Superoxide Dismutase and Catalase", Circulation Research, vol. 54, No. 3, Mar. 1984, pp. 227-285.
"Drugs May Help Revive Brain Dead", Asscociated Press, The Cincinnati Post, Thursday, Oct. 2, 1986.
R. Del Maestro, "Systemic Consequences of O.sub.2 Production", Section 49 of Methods in Enzymology, vol. 105, (1984), Academic Press.
"Oxidation of OH Scavengers and Alcohols", Section 68 of Methods in Enzymology, vol. 105, pp. 517-518, (1984) Academic Press.
Bo K. Siesjo, "Review Cell Damage in the Brain: A speculative Synthesis", Journal of Cerebral Blood Flow and Metabolism, 1:155-185, 1981 Raven Press, New York.
P. O. Seglen, "Preparation of Rat Liver Cells III, Enzymatic Requirements for Tissue Dispersion", Experimental Cell Research 82 (1973) pp. 391-398.
Chien et al., "Microsomal Membrane Dysfunction in Ischemic Rat Liver Cells", Abstract of Biochemistry and Biophysics 180, 191-198 (1977).
Marubayashi et al., "Role of Free Radicals in Ischemic Rat Liver Cell Injury: Prevent Damage by alpha-tocopherol Administration", Surgery vol. 90, No. 2, Feb. 1986, pp. 184-191.
Lyon et al., "Relationship Between Alcohol Intoxification and the Ordering of Brain Membranes by A Series of Short-Chain Alcohols", Journal of Pharmocology and Experimental Therapeutics, vol. 218, No. 3, 1981, pp. 669-675.
Dorfman et al., "Reactivity of the Hydroxyl Radical in Aqueous Solutions", U.S. Dept. of Commerce, National Bureau of Standards, (1973).
Ambrosio et al., "Reduction in Experimental Infarct Size by Recombinant Human Superoxide Dismutose:Insights into the Pathophysiology of Reperfusion Injury", Circulation 74, No. 6, 1424-1433, 1986.
Sakurai et al., Chem Abst. 106(13):95942c (1987).
Arfors et al., Chem. Abst. 104(26):230491f (1986).
Bernauer, Walter, Chem. Abst. 105(15):12959g (1986).
Raleigh et al., Chem. Abst. 99(23):190652d (1983).
Cohen et al., Chem. Abst. 86(1):656u (1977).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for alleviating ischemic-reperfusion injury does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for alleviating ischemic-reperfusion injury, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for alleviating ischemic-reperfusion injury will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1891008

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.