Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1984-06-29
1987-02-24
Jilan, Henry R.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
548403, 548565, 548579, 546263, 546189, 514476, 514483, 514332, 514316, 514422, 558235, 558236, 558237, 558238, A61K 4900, C07D20700/207/18, C07D20706
Patent
active
046456619
ABSTRACT:
A method for alleviating cisplatin compound-induced nephrotoxicity in animals comprising administering to the animal an effective amount of a polar dithiocarbamate compound. The polar dithiocarbamate compounds have the formula: ##STR1## In the above formula, R.sup.1 and R.sup.2 are hydrocarbon groups and R.sup.1, R.sup.2, or both R.sup.1 and R.sup.2 contain a polar group substituted thereon. M is a pharmaceutically acceptable cation and n is an integer of from 1 to 3.
Novel polar dithiocarbamate compounds are disclosed as well.
REFERENCES:
patent: 3051625 (1962-08-01), Rao
patent: 4177263 (1979-12-01), Rosenburg et al.
patent: 4310515 (1982-01-01), Granatek et al.
patent: 4339437 (1982-07-01), Rosenberg et al.
Morrison et al., Organic Chemistry, Third Edition, New York University, pp. 327-328.
Elliott, W. C., et al., Cancer Research, 43: 3759-3762 (1983).
Jones, S. G., et al., Research Communications in Chemical Pathology and Pharmacology, 40: 155-163 (1983).
Gale, G. R., et al., Ibid., 41: 293-302 (1983).
Jilan Henry R.
St. Jude Children's Research Hospital
Whittenbaugh Robert C.
LandOfFree
Method for alleviating cisplatin-induced nephrotoxicity and dith does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for alleviating cisplatin-induced nephrotoxicity and dith, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for alleviating cisplatin-induced nephrotoxicity and dith will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-108446