Surgery – Means for introducing or removing material from body for... – Material introduced into and removed from body through...
Patent
1986-06-24
1989-05-23
Lovering, Richard D.
Surgery
Means for introducing or removing material from body for...
Material introduced into and removed from body through...
264 46, 424 852, 424426, 424463, 424486, 424497, 514885, 514965, 6048911, A61K 922, A61K 926, A61M 3100
Patent
active
048326860
ABSTRACT:
A biocompatible, biodegradable, bioerodible composite polymer matrix comprising interleukin-2 in an appropriate polymer. The polymer may be a polymer or copolymer of lactic acid, lactide, glycolide, glutamic acid, or it may be collagen or albumin. The material contains from 10.sup.2 to 10.sup.8 U IL-2/g of polymer. Also disclosed is a method for making the composite polyer matrix and a method for implanting the material. A soft, malleable controlled-release composite material may be used for intracranial or other implantation and may be shaped or molded to fit the site from which malignant tissue has been removed, opposing the residual tumor, complementing hemostasis, compatible with anatomical structure, and functioning as an implantable immunotherapeutic adjuvant.
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