Method for administering insulin to the buccal region

Details Method for administering insulin to the buccal region Method for administering insulin to the buccal region

2006-07-04

2006-07-04

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S435000, C424S400000

Reexamination Certificate

active

07070799

ABSTRACT:
A mixed micellar pharmaceutical formulation includes a micellar proteinic pharmaceutical agent, an alkali metal C8 to C22 alkyl sulfate, alkali metal salicylate, a pharmaceutically acceptable edetate and at least one absorption enhancing compounds. The absorption enhancing compounds are selected from the group consisting of lecithin, hyaluronic acid, pharmaceutically acceptable salts of hyaluronic acid, octylphenoxypolyethoxyethanol, glycolic acid, lactic acid, chamomile extract, cucumber extract, oleic acid, linolenic acid, borage oil, evening primrose oil, trihydroxy oxo cholanylglycine, glycerin, polyglycerin, lysine, polylysine, triolein and mixtures thereof. Each absorption enhancing compound is present in a concentration of from 1 to 10 wt./wt. % of the total formulation, and the total concentration of absorption enhancing compounds are less than 50 wt./wt. % of the formulation. Methods for administering insulin to the buccal region are also disclosed.

REFERENCES:
patent: 4835138 (1989-05-01), Alexander et al.
patent: 4849227 (1989-07-01), Cho
patent: 4948588 (1990-08-01), Kamiya et al.
patent: 4963556 (1990-10-01), Alexander et al.
patent: 5023252 (1991-06-01), Hseih
patent: 5049389 (1991-09-01), Radhakrishnan
patent: 5179079 (1993-01-01), Hansen et al.
patent: 5200393 (1993-04-01), Weiner
patent: 5230884 (1993-07-01), Evans et al.
patent: 5273965 (1993-12-01), Kensil et al.
patent: 5376646 (1994-12-01), Pittrof et al.
patent: 5536444 (1996-07-01), Hettche et al.
patent: 5663198 (1997-09-01), Reul et al.
patent: 5672581 (1997-09-01), Rubsamen et al.
patent: 5676931 (1997-10-01), Adjei et al.
patent: 5707641 (1998-01-01), Gertner et al.
patent: 5747445 (1998-05-01), Backstrom et al.
patent: 5770559 (1998-06-01), Manning et al.
patent: 6432383 (2002-08-01), Modi
patent: 0200383 (1986-12-01), None
patent: 0463653 (1992-01-01), None
patent: WO99/16417 (1999-04-01), None
patent: WO00/47203 (2000-08-01), None
B.J. Aungst and N.J. Rogers,Comparison of Nasal, Rectal, Buccal, Sublingual and Intramuscular Insulin Efficacy and the Effects of a Bile Salt Absorption Promoter, The Journal of Pharmacology and Experimental Therapeutics, (Sep. 21, 1987), pp. 23-27, vol. 244, No. 1, The American Society for Pharmacology and Experimental Therapeutics.
B.J. Aungst and N.J. Rogers,Site Dependence of Absorption-Promoting Actions of Laureth-9, Na Salicylate, Na2EDTA, and Aprotinin on Rectal, Nasal, and Buccal Insulin Delivery, Pharmaceutical Research, (1988), pp. 305-308, vol. 5, No. 5, Plenum Publishing Corporation.
B.J. Aungst and N.J. Rogers,Comparison of the effects of various transmucosal absorption promoters on buccal insulin delivery, International Journal of Pharmaceutics, (1989) pp. 227-235, vol. 53, Elsevier Science Publishers B.V.
A.H. Shojaei,Buccal Mucosa As a Route for Systemic Drug Delivery: A Review, J Pharm Pharmaceut Sci, (1998), pp. 15-30, vol. 1(1).

Affiliated with

Also associated with

Rating

Method for administering insulin to the buccal region does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for administering insulin to the buccal region, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for administering insulin to the buccal region will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3564665